Registration Dossier
Registration Dossier
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EC number: 277-146-9 | CAS number: 72968-71-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- Five male and 5 female rats received a single dose of 10000 mg Termoplast Lm/400 (35% suspension in Carboxymethyl cellulose)/kg bw by gavage. The animals were observed for mortality, clinical signs and body weight for 14 days. A histopathological examination was performed at the end of the study.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl 4-cyano-5-[[5-cyano-2,6-bis[(3-methoxypropyl)amino]-4-methyl-3-pyridyl]azo]-3-methyl-2-thenoate
- EC Number:
- 277-146-9
- EC Name:
- Methyl 4-cyano-5-[[5-cyano-2,6-bis[(3-methoxypropyl)amino]-4-methyl-3-pyridyl]azo]-3-methyl-2-thenoate
- Cas Number:
- 72968-71-9
- Molecular formula:
- C23H29N7O4S
- IUPAC Name:
- methyl 4-cyano-5-[[5-cyano-2,6-bis[(3-methoxypropyl)amino]-4-methyl-3-pyridyl]azo]-3-methyl-2-thenoate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Test material name given in the report: Thermoplastrot Lm 74/400
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Carboxymethylcellulose 0.5% in water
- Doses:
- 10000 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 5 female rats/dose
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No feaths
- Clinical signs:
- other: Faeces were coloured dark red
- Gross pathology:
- No abnormalities detected
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 > 10000 mg/kg bw (discriminating dose).
- Executive summary:
Five male and 5 female rats received a single dose of 10000 mg Termoplast Lm/400 (35% suspension in Carboxymethyl cellulose)/kg bw by gavage. The animals were observed for mortality, clinical signs and body weight for 14 days. A histopopathological examination was performed at the end of the study. No mortalities occurred. Discriminating dose = 10000 mg/kg bw.
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