Cholest-5-en-3-β-yl acetate

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 21 March 2018 to 25 April 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

2016

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Version / remarks:

1996

Deviations:

no

GLP compliance:

yes

Type of method:

effusion method: isothermal thermogravimetry

Test material

Test material information

Constituent 1

Reference substance name:

Cholest-5-en-3-β-yl acetate

EC Number:

210-066-4

EC Name:

Cholest-5-en-3-β-yl acetate

Cas Number:

604-35-3

Molecular formula:

C29H48O2

IUPAC Name:

(1R,3aS,3bS,7S,9aR,9bS,11aR)-9a,11a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-yl acetate

Test material form:

solid: particulate/powder

Details on test material:

- Appearance: White crystalline powder
- Storage condition: At room temperature

Results and discussion

Vapour pressure

Vapour pressure 1

Key result

Temp.:

20 °C

Vapour pressure:

<= 0 Pa

Vapour pressure 2

Key result

Temp.:

25 °C

Vapour pressure:

<= 0 Pa

Any other information on results incl. tables

Table: Results of the isothermal TGA analysis (test item)

Temperature [°C]	Weight loss [µg/min]	νT [g/cm^2/h]	log νT	log PT	PT [Pa]
160	1.79638	2.14E-4	-3.67	0.44	2.8
	1.60690	1.92E-4	-3.72	0.38	2.4
170	3.70022	4.42E-4	-3.35	0.84	7.0
	3.23680	3.86E-4	-3.41	0.77	5.9
180	6.84120	8.17E-4	-3.09	1.18	15
	6.19528	7.40E-4	-3.13	1.13	13
190	11.5687	1.38E-3	-2.86	1.48	30
	10.7674	1.29E-3	-2.89	1.44	27

 

Applicant's summary and conclusion

Conclusions:

The vapour pressure of the substance at 20°C was determined to be ≤ 5.0E-8 Pa.
The vapour pressure of the substance at 25°C was determined to be ≤ 1.3E-7 Pa.

Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study according to EC A.4, OECD 104 and OPPTS 830.7950.

The constants specific for the experimental arrangement were determined using a set of 5 reference compounds. A vapour pressure curve for the test item was constructed from duplicate measurements at 160°C, 170°C, 180°C and 190°C. The vapour pressure of the substance at 20°C and 25°C was calculated by extrapolation to be 5.0E-8 Pa and 1.3E-7 Pa, resp. Since the weight losses of the test item were obtained with a temperature program of above the melting temperature of the test item, the vapour pressure of the test item could be slightly overestimated. The vapour pressure of the substance at 20°C and 25°C was therefore reported as ≤ 5.0E-8 Pa and ≤ 1.3E-7 Pa, resp.