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Diss Factsheets
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EC number: 483-270-6 | CAS number: 54068-28-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: sub-chronic inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no guideline, well ducumented study
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- subchronic neurotoxicity:
6h / day, 5 days / week, 14 weeks
- Animals were observed daily for sinces of toxic and/or pharmacologial effects
- Monthly Irin screeb test an before first exposure
- Necropsy of brain, lumbar spinal cord, tibal and sciatic nerves
- additional histologials examination: (1. celebral cortex and main body candate nucleus putamen, 2. celebral cortex with thalamus and hyphothalamus, 3. celebral cortex with nidbrain, 4. cerebellum and pons, 5. meilla obongata) - GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Pentane-2,4-dione
- EC Number:
- 204-634-0
- EC Name:
- Pentane-2,4-dione
- Cas Number:
- 123-54-6
- IUPAC Name:
- pentane-2,4-dione
- Reference substance name:
- 2,4-pentadione
- IUPAC Name:
- 2,4-pentadione
- Details on test material:
- 2,4-Pentadione, Purity 99%
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- air
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- acute study: 1250, 1850 ppm for 4 h
subchronic sturdy: 100, 300, 650 ppm for 6h - Frequency of treatment:
- acute study: 1 time, 4 hours
subchronic sturdy: 6h, 5 days per wk, 14 wk
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
acute: 1250 ppm
Basis:
other: concentration in air
- Remarks:
- Doses / Concentrations:
1acute: 1850 ppm
Basis:
other: concentration in air
- Remarks:
- Doses / Concentrations:
subchronic: 100 ppm
Basis:
other: concentration in air
- Remarks:
- Doses / Concentrations:
subchronic: 300 ppm
Basis:
other: concentration in air
- Remarks:
- Doses / Concentrations:
subchronic: 650 ppm
Basis:
other: concentration in air
- No. of animals per sex per dose:
- acute study: 10 male and female per concentration
subchronic sturdy: 100, 200 ppm: 20 male and female, 650 ppm: 30 male, 20 female - Control animals:
- other: only exposured to air
Results and discussion
Any other information on results incl. tables
not relevant, in due no developmental study
Applicant's summary and conclusion
- Conclusions:
- In due in absence of adverse effects in the groups exposed to concentrations of 101 and 307 ppm the NOEC (subchronic) is ste to 307 ppm.
- Executive summary:
1. Male and female Fischer 344 rats were exposed to 2,4-pentanedione (2,4-PD) vapour acutely (4 h) at 1265 or 1811 ppm, or for 6 h day-1, 5 days a week for 14 weeks to 0, 101, 307 or 650 ppm. 2. Mortality occurred during or within a few hours of the acute exposures (10% at 1265 ppm; 70% at 1811 ppm). No animal had gross or microscopic brain lesions. 3. All female rats (20) and 10 of 30 male rats exposed to 650 ppm 2,4-PD vapour died by the 38th study day (29 exposures); there were no subsequent male deaths. Twenty-five of the 30 animals that died, and seven of the 15 males that survived, had light microscopical evidence of degenerative lesions, principally within the caudate/putamen nuclei, nuclei of the cerebellar medulla, and vestibular nuclei. Less frequently involved, in animals that died, were various regions of the cerebral cortex. The early histopathological lesions, seen from the 16th study day (12 exposures) to the 38th study day (28 exposures) were characterised by malacia. When present, lesions in male rats surviving the 14-weeks of 650 ppm 2, 4-PD exposure were characterised by malacia and gliosis. No peripheral nerve lesions were seen by light or transmission electron microscopy. 4. Neither mortality nor neuropathology were seen in rats subchronically exposed to 101 or 307 ppm, 2,4-PD vapour.
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