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Diss Factsheets
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EC number: 239-554-5 | CAS number: 15519-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-07-02 to 2010-07-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and OECD Guideline compliant study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Human Skin Model Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Caesium carbonate
- EC Number:
- 208-591-9
- EC Name:
- Caesium carbonate
- Cas Number:
- 534-17-8
- Molecular formula:
- CH2O3.2Cs
- IUPAC Name:
- Cesium carbonate
- Test material form:
- solid: crystalline
Constituent 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: formazan production in comparison to the negative control
- Basis:
- mean
- Remarks:
- test item
- Time point:
- other: 3 min
- Score:
- 102.6
- Reversibility:
- other: not applicable in in vitro studies
- Irritation parameter:
- other: formazan production in comparison to the negative control
- Basis:
- mean
- Remarks:
- test item
- Time point:
- other: 1 h
- Score:
- 47.4
- Reversibility:
- other: not applicable in in vitro studies
- Irritation parameter:
- other: formazan production in comparison to the negative control
- Basis:
- mean
- Remarks:
- positive control
- Time point:
- other: 3 min
- Score:
- 25.5
- Reversibility:
- other: not applicable in in vitro studies
- Irritation parameter:
- other: formazan production in comparison to the negative control
- Basis:
- mean
- Remarks:
- positive control
- Time point:
- other: 1 h
- Score:
- 20.3
- Reversibility:
- other: not applicable in in vitro studies
Applicant's summary and conclusion
- Interpretation of results:
- other: not corrosive
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- According to OECD Guideline 431 study the test item is considered to be not corrosive.
- Executive summary:
The test item is considered to be not corrosive. After three minutes treatment, the relative absorbance values were decreased to 102.6 %. This value is well above the threshold for corrosivity (50 %). After one hour treatment relative absorbance values were reduced to 47.4 %. This value is well above the threshold for corrosivity (15 %). The values of the negative control were well above the required acceptability criterion of mean OD > 0.8 for both treatment interval thus showing the quality of the tissues. The value of the positive control induced a decrease in the relative absorbance as compared to the negative control to 25.5 % for the three minutes treatment interval and 20.3 % for the one hour treatment interval thus ensuring the validity of the test system. Although the value of the one-hour-experiment was 20.3 % and therefore higher than the threshold for corrosivity, this is considered as not relevant, as a clear corrosive effect was determined and values above 15 % have been measured for the positive control before: Values for the positive control were within the range of historical data of the test facility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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