Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 825-246-3 | CAS number: 2098351-38-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21-25 October 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Good quality study under GLP, however no chemical analyses and no certificate of analysis or detailed description of the test substance. Therefore concentrations nominal.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- no chemical analysis, fish slightly bigger than required
- Principles of method if other than guideline:
- no chemical analyses
fish were slightly bigger than recommended, however this was considered not to have influenced the final results. - GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Details on sampling:
- no chemical analyses
- Details on test solutions:
- Direct dispersion in water. 4.0 g of test material were dispersed in 1 litre of diluent to give the stock solution of 4.0 g/l from which serial dilutions
were made to give the test series.
The test material was suspected to absorb to glassware and so saturation of the absorption sites was achieved by soaking the test vessels
overnight prior to the start of the test with the test solutions. At 0 hours the test vessels were emptied, rinsed with the solution to be tested
and then refilled with the fresh test solution. - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Rainbow trout (Oncorhynchus mykiss)
Source: Parkwood trout farm, Wigmore, kent, United Kingdom.
The stock of fish was held since 11 September 1991 and was acclimatised to test conditions from 14 -21 October 1991.
The stock fish were maintained in a glass fibre tank with a single-pass water renewal system. The light was controlled to give a 16h light and 8h
darkness cycle. Fish were fed dailey with commercial trout pellets, but feeding was discontinued 24h prior to the test.
Mean standard length = 6.4 cm (SD = 0.5 cm), mean weight = 3.40 g (SD = 0.58 g), no data on age of fish. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- no
- Hardness:
- aproximately 50mg/L as CaCO3
- Test temperature:
- 14ºC
- pH:
- 7.2-7.3
- Dissolved oxygen:
- 10.0 -10.1 mg O2/L
- Salinity:
- no data
- Nominal and measured concentrations:
- Nominal concentrations: 1.0, 1.4, 3.2, 5.6 and 10 mg/l.
- Details on test conditions:
- The test material was suspected to absorb to glassware and so saturation of the absorption sites was achieved by soaking the test vessels overnight prior to the start of the test with the test solutions. At 0 hours the test vessels were emptied, rinsed with the solution to be tested and then refilled
with the fresh test solution.
There was a dailey renewal of test media to ensure stability of the test concentrations.
The lightning was controlled at 16h light- 8 h darkness cycle.
Test vessels: Glass aquaria holding 40L of test media. 5 test concentration in duplicate, plus 1 control (10 animals per test concentration).
Fish were placed at random in prepared test media, loading 0.85 g bodyweight/L.
Aeration via narrow bore glass tubes.
Criteria of death: absence of (i) respiratory movement and (ii) response to a physical stimulation. - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 3.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95%CL (3.2-4.4 mg/L)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Results with reference substance (positive control):
- no reference substance tested
- Reported statistics and error estimates:
- 96 h LC50=3.8 mg/L with 95% CL of 3.2-4.4 mg/L
- Validity criteria fulfilled:
- yes
- Conclusions:
- Good quality study, however no chemical analyses therefore concentrations nominal.
- Executive summary:
TEST CONDITIONS: Semi-static test conditions accordi ng to OECD Guideline No. 203 referenced as Method C. 1 of Commission Directive 84/449/EEC (which constitutes Annex V of Council Directive 67/584/EEC)
RESULTS:
LC50 (96h) 3.8 mg/L which equals 1.1 mg a.i./L
95% condidence limits: 3.2 - 4.4 mg/L which equals 0.93 - 1.3 mg a.i./L
ai = active ingredient
"No Observed Effect Concentration" (NOEC) 1.8 mg/l (0.51 mg ai/l)
Reference
Description of key information
In a s semi-static test conditions according to OECD Guideline No. 203 the LC50 (96h) was determined to 1.1 mg/L (Based on active active ingredient)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.1 mg/L
Additional information
One acute fish study with Amines, N-C12 -18 -alkyltrimethylenedi-, reaction products with chloroacetic acid, sodium salts is available. The study is performed semi-statically according to OECD 203. Similar to other studies from this period it lacks the quantification of the test substance during the test. When these studies were performed no suitable sensitive analytical method was available for the quantification of this test substance. The study from Handley & Wetton (1992) resulted in a 96h LC50 for rainbow trout of 1.1 mg a.i./L based on nominal test concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.