Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-815-9 | CAS number: 100-06-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973-08-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- In principle similar to OECD Guideline 406
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Human Patch Test with with 25 volunteers. No controls with control subjects were carried out, but a preliminary study with a mild irritant reference substance (sodium lauryl sulfate) for reliability check was conducted. This method is based on the visual assessement of erythrema as indicator of contact allergic response in previously sensitized test persons.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4'-methoxyacetophenone
- EC Number:
- 202-815-9
- EC Name:
- 4'-methoxyacetophenone
- Cas Number:
- 100-06-1
- Molecular formula:
- C9H10O2
- IUPAC Name:
- 1-(4-methoxyphenyl)ethanone
Constituent 1
Method
- Type of population:
- not specified
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed:
- Sex: Male
- Age: 22-62
- Demographic information: None - Clinical history:
- Healthy. Not further specified.
- Controls:
- None
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: Patch test (epicutaneous test)
ADMINISTRATION
- Type of application: Epicutaneous, occlusive
- Description of patch: None
- Vehicle / solvent: Unchanged (no vehicle)
- Concentrations: 6%
- Volume applied: Not specified
- Testing/scoring schedule: Not specified
- Removal of test substance: Not specified
EXAMINATIONS
- Grading/Scoring system: Not specified
- Statistical analysis: None
Results and discussion
- Results of examinations:
- SYMPTOMS
- Frequency, level, duration of symptoms observed: None
NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions (48 h and 72 h after challenge): 0
- Number of subjects with negative reactions (48 h and 72 h after challenge): 25
- Number of subjects with equivocal reactions (48 h and 72 h after challenge): 0
- Number of subjects with irritating reactions (48 h and 72 h after challenge): 0
RESULTS
- 1st reading (48 h after challenge): No indication of skin sensitisation
- 2nd reading (72 h after challenge): No indication of skin sensitisation
Any other information on results incl. tables
Table: Results of the Maximization Test
|
Challenge |
|||
Subject No. |
Age |
Race |
48-hrs. |
72-hrs. |
1 |
24 |
B |
0 |
0 |
2 |
27 |
B |
0 |
0 |
3 |
40 |
B |
0 |
0 |
4 |
22 |
B |
0 |
0 |
5 |
23 |
B |
0 |
0 |
6 |
32 |
B |
0 |
0 |
7 |
22 |
B |
0 |
0 |
8 |
36 |
B |
0 |
0 |
9 |
28 |
B |
0 |
0 |
10 |
28 |
B |
0 |
0 |
11 |
39 |
B |
0 |
0 |
12 |
22 |
B |
0 |
0 |
13 |
31 |
B |
0 |
0 |
14 |
46 |
B |
0 |
0 |
15 |
49 |
B |
0 |
0 |
16 |
25 |
B |
0 |
0 |
17 |
62 |
B |
0 |
0 |
18 |
39 |
B |
0 |
0 |
19 |
23 |
B |
0 |
0 |
20 |
23 |
B |
0 |
0 |
21 |
25 |
B |
0 |
0 |
22 |
25 |
B |
0 |
0 |
23 |
30 |
B |
0 |
0 |
24 |
24 |
B |
0 |
0 |
25 |
24 |
B |
0 |
0 |
Applicant's summary and conclusion
- Conclusions:
- Based on the result of this test, the test item has no skin sensitizing potential.
- Executive summary:
The skin sensitising potential of the test item was assessed in a Human Patch Test. Twenty-five healthy male volunteers at age between 22 and 65 years were exposed to the test substance for a five alternate-day 48-hour period. A preliminary study confirmed that sodium lauryl sulfate is suitable for pretreatment in the main test. For pre-treatment, a 5% sodium lauryl phosphate was applied to the patch sites for a duration of 24 hours. After a rest period of ten days, a 10% aquaous solution of sodium lauryl sulfate was applied under occlusion. Afterwards the volunteers were challanged with patches of the test item, applied for 48 hours to fresh sites (occlusive). After 48 hours of exposure the patches were removed and the sites were examined subsequently and 24 hours thereafter. In result there were no signs of contact-sensitisation observeable after a challenge period of 48 and 72 hours (mean score = 0, no visible change). It can be concluded that the test item has no skin sensitizing potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.