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Diss Factsheets
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EC number: 207-987-9 | CAS number: 504-24-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- A Summary of the Acute Toxicity of 4-Aminopyridine to Birds and Mammals
- Author:
- EDWARD W. SCHAFER, JR., RONALD B. BRUNTON AND DONALD J. CUNNINGHAM
- Year:
- 1 973
- Bibliographic source:
- TOXICOLOGY AND APPLIED PHARMACOLOGY 26, 532-538 U.S. Bureau of Sport Fisheries and Wildlife, Wildlife Research Center, Denver, Colorado 80225
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Previously unpublished data from the Denver Wildlife Research Center (DWRC) were derived primarily by the po methods described by DeCino et al. (1966), Schafer (1972), and Schafer et aÍ. (1967). Other methods of oral administration included force-feeding synthetic pellets (Pan and Caslick, 1966) or treated grain. Dermal toxicity was determined by the method described by Schafer et al. (1969). All test animals were adults unless noted in the table. LD50 values and 95 % confidence limits were derived by the moving-point interpolation method described by Thompson (1948), Thompson and Weil (1952), and Weil (1952). The 4AP used was technical material of about 95% purity.
Methodology for other data can be found in the cited articles. - GLP compliance:
- not specified
- Test type:
- other: not specified
Test material
- Reference substance name:
- 4-pyridylamine
- EC Number:
- 207-987-9
- EC Name:
- 4-pyridylamine
- Cas Number:
- 504-24-5
- Molecular formula:
- C5H6N2
- IUPAC Name:
- nickel
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 20 mg/kg bw
- Based on:
- test mat.
- Other findings:
- 4-Aminopyridine (4AP) is an acutely toxic substituted pyridine. In mammals, it produces the following sequence of clinical signs: hyperexcitability, salivation, tremors, muscular incoordination, clonic and tonic convulsions, cardiac or respiratory arrest, and death. At doses near the LD50, initial effects are usually noted in 10-15 min and death often occurs 15 min to 4 hr later. Occasionally, the tremor and/or convulsive stages are accompanied by audible vocalizations produced by strong, involuntary contractions of the diaphragm.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- LD50 (rat, oral): 20 mg/kg bw
- Executive summary:
LD50 (rat, oral): 20 mg/kg bw (toxikology review: EPA TSCA Inventory)
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