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Diss Factsheets
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EC number: 284-009-7 | CAS number: 84776-83-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16/06/1990 to 22/06/1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Resin acids and Rosin acids, esters with trimethylolpropane
- EC Number:
- 284-009-7
- EC Name:
- Resin acids and Rosin acids, esters with trimethylolpropane
- Cas Number:
- 84776-83-0
- Molecular formula:
- UVCB substance - Molecular formula Not applicable for UVCBs
- IUPAC Name:
- Resin acids and Rosin acids, esters with trimethylolpropane
- Test material form:
- solid
- Details on test material:
- Vapour pressure: less than 1.4 x 10-3 Pa at 25 °C
Water solubility: 0.06.09x10-4 kg/m-4 g/l
Density: 1.07 x10³ kg/m³ at 19.8 ∓ 0.5 °C
Appearance: pale yellow solid
Melting point: 24.2 to 51.2 ± 0.5 °C (297 to 324 ± 0.5 K)
Boiling point: 418 ± 0.5 °C (691 ± 0.5 K) at 100.9 kPa.
Constituent 1
- Specific details on test material used for the study:
- Test Material: Bevilite 62-85
Appearance: yellow grains
Lot Number: 010121
Source: Bergvik France
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Abbaye de Bellefontaine
- Acclimatation: 5 days
- Mean weight: 2.6 =/-0.1 Kg
- Identification: metallic ear-tags
- Housing: Individual cages
- Room: air conditioned animal room
- Temperature: 20 =/- 3 °C
- Hygrometry: 50 =/- 20% relative humidity
- Light/dark cycle: 12 hours light/ 12 hours dark
- Food: ad libitum
- Water: always available
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- A dose of 500 mg of the test substance ground to a fine dust was applied to a 6 cm2 pre-moisted hydrophilic gauze patch saturated with 0.5 ml of water for injectable preparation and this was then applied to the right flank of each animal.
The left flank did not receive any substance and served as a control.
The test substance and the hydrophilic gauze patch were held as a control. The test substance and the hydrophilic gauze patch were held in contact with the skin for 4 hours by means of a adhesive hypoallergic aerated semi occlusive dressing attached to the gauze bandage. - Duration of treatment / exposure:
- The single application was performed on the 12.06.90. The animals were kept under observation until the 15.06.90
- Observation period:
- The animals were kept under observation until the 15.06.90
- Number of animals:
- 6 rabbits
- Details on study design:
- Please, see "Any other information on material and methods"
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Rabbits exposed to the test material Bevilite 62-85 did not show cutaneous reactions.
- Executive summary:
The cutaneous irritation potential of the test material Bevilite 62-85 was determined according the OECD 404 Guideline and under GLP conditions.
Six New Zealand rabbit were used in this study. The day before the treatment, the flanks of each animal were partially clipped with an electrical clipper. Only animals showing no obvious signs of irritation were used for this study.
A dose of 500 mg of the test substance ground to a fine dust was applied to a 6 cm2 pre-moisted hydrophilic gauze patch saturated with 0.5 ml of water for injectable preparation and this was then applied to the right flank of each animal.
The left flank did not receive any substance and served as a control. The test substance and the hydrophilic gauze patch were held as a control. The test substance and the hydrophilic gauze patch were held in contact with the skin for 4 hours by means of an adhesive hypoallergic aerated semi occlusive dressing attached to the gauze bandage. Subsequently, the dressing were removed and the animals were placed back into their individuals cages.
The test substance was not rinsed off after treatment.
Observations for erythema and oedema were done at 1 hr, 24 hr, 48 hr and 72 hr after the treatment. The result of the study showed no cutaneous reactions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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