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Diss Factsheets
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EC number: 947-618-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Radiolabelling:
- no
- Details on study design: HPLC method:
- Chromatograph: High Performance Liquid Chromatograph, Agilent 1100
Chromatographic conditions:
Column type: length: 250 mm, inner diameter: 4 mm Stationary Phase: LiChrospher 100 CN, particle diameter: 5 μm Supplier: Fa. Merck
Mobile Phase: 415 mL demineralized water (Millipore) + 85 mL buffer pH 6 + 500 mL acetonitrile (isocratic)
Flow rate: 0.5 mL/min Column Temperature: 40 °C Detection: UV, 220 nm Injection volume: 3 μL
Determination of the dead time was performed using sodium nitrate. - Analytical monitoring:
- not required
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- ca. 0.5 - ca. 0.9
- pH:
- 7
- Temp.:
- 25 °C
- Details on results (HPLC method):
- Capacity factor: k’ = (tR - t0)/t0
tR = retention time of substances;
t0 = dead time
Effective correlation: log k’ = a + b log Koc
Linear regression gives:
a = - 0.5020
b = 0.2307
r = 0.9755
where a and b = regression factor and r = correlation factor - Validity criteria fulfilled:
- yes
- Conclusions:
- The logKoc of the substance is in the range of about 0.5 to 0.9 (2 peaks). The results are below the logKoc value of the reference substance with the lowest logKoc (1.45). Therefore the extrapolated values were taken for assessment.
- Executive summary:
In a test according to OECD 121 (HPLC method) the logKoc of Reaction mass of 2-(3-{6-[3-(2-Hydroxyethyl)-3-methylureido]hexyl}-1-methylureido)ethanol and 6-[3-(2-Hydroxyethyl)-3-methylureido]hexylamino 3-(methylamino)propionate ("EGGE 2806 -1") was determined. The substance consists of 2 isomers which have slighly different retention behaviour under the conditions of the guideline. Individual log Koc value were reported to be 0.5 and 0.9. However the study used only reference substances with a logKoc >1.5. Therefore the study report stated a Koc value of <1.5. Re-evaluation however allows to report the individual values obtained by extrapolation. This is justified as the replicates of retention times were stable (typically +-0.001 min) and the linear regression yielded a correlation coefficient of >0.97.
Reference
Mean value of 3 single values of the test item EGGE 2806-1
Retention time [tr] = min | Capacity factor k’ | Log k’ | Log Koc | |
EGGE 2806-1 peak 1 (main component, 60%) | 4.738 +-0.001 | 0.410 | -0.3867 | 0.500 |
EGGE 2806-1 peak 2 (minor component, 23%) | 5.039 +- 0.001 | 0.500 | - 0.3010 | 0.871 |
Description of key information
In a test according to OECD 121 (HPLC method) the logKoc of Reaction mass of 2-(3-{6-[3-(2-Hydroxyethyl)-3-methylureido]hexyl}-1-methylureido)ethanol and 6-[3-(2-Hydroxyethyl)-3-methylureido]hexylamino 3-(methylamino)propionate ("EGGE 2806 -1") was determined. The substance consists of 2 isomers which have slighly different retention behaviour under the conditions of the guideline. Individual log Koc value were reported to be 0.5 and 0.9. However the study used only reference substances with a logKoc >1.5. Therefore the study report stated a Koc value of <1.5. Re-evaluation however allows to report the individual values obtained by extrapolation. This is justified as the 3 replicates of retention times were stable (typically +-0.001 min) and the linear regression yielded a correlation coefficient of >0.97.
The lowest logKoc value was choosen as key information as this reprensents the worst when using EPM for calculating effects values in soil and sediment from aquatic toxicity data.
Key value for chemical safety assessment
- Koc at 20 °C:
- 3.2
Additional information
[LogKoc: 0.5]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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