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EC number: 220-543-9 | CAS number: 2802-68-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
In a GLP-compliant acute oral toxicity study performed according to EU
Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method) (BASF,
1995), the substance was administered to rats via gavage in olive oil at
doses of 200 and 2000 mg/kg. No mortality was observed at 200 mg/kg,
whereas all animals in the 2000 mg/kg group died within 3 hours after
administration. Clinical signs included impaired general state and
dyspnea at 200 mg/kg and poor general state, dyspnea, apathy, staggering
ataxia, paresis and cyanosis at 2000 mg/kg. The animals in the 2000
mg/kg group showed hemorrhages in the mucosa of the glandular stomach
and substance discoloration of contents in the small intestines.
No experimental data on acute inhalation or acute dermal toxicity with the complex of boron trifluoride with methanol are available. Boron trifluoride is classified as skin and eye corrosive and consequently the complex can also be regarded as corrosive, which was confirmed in a Skin corrosion study in rabbits according to OECD Guideline 404 (see IUCLID section 7.3.1).
The following studies (read-across) conducted with boron trifluoride, boron trifluoride dihydrate and methanol further underline the acute toxicity / corrosiveness of the complex.
Acute inhalation toxicity:
-Key / Read across to boron trifluoride dihydrate:
In a publication of Rusch et al. from 1986,
groups (5/sex) of Fischer 344 rats (approx. 7 weeks old) were treated
whole body via inhalation route with the read across substance boron
trifluoride dihydrate (CAS No. 13319-75-0). Animals were exposed for 4
hours at concentrations of 1.01, 1.22, 1.32 and 1.54 mg/L. Animals were
then observed for 14 days. All animals were examined at the end of the
chamber equilibration period, at 0.25, 0.5, 0.75 and 1h during exposure,
at 0, 1, 2 and 24 h post exposure and daily during the 14-day
post-exposure observation period. Body weights were recorded on days 1,
2, 4, 7 and 14. Necropsy was performed on all animals.
Mortality was observed in all dosing groups: 3/10 (1.01 mg/L), 2/10
(1.22 mg/L), 8/10 (1.32 mg/L) and 9/10 (1.54 mg/L). Observed clinical
signs included dry and moist rales, gasping, excessive oral and nasal
discharge, and lacrimation, indicative of respiratory distress and
irritation. Recovery was apparent for the rats surviving beyond study
day 6 post exposure.
The LC50 (4 h) was calculated to be around 1210 mg/m3 when rats were
whole body exposed by inhalation to aerosols of BF3 dihydrate.
-Supporting / Read across to boron trifluoride and boron trifluoride
dihydrate:
The acute inhalation toxicity of the read across substance boron
trifluoride dihydrate (CAS No. 13319-75-0) was evaluated in a 4-hour,
single-exposure study in rats according to a protocol comparable to the
OECD Guideline 403 (Rusch et al., 2008). The test substance was
initially administered to a single group of ten male and ten female
Sprague Dawley rats via whole-body exposure at concentrations of 0, 10,
30, 100 mg/m3 (nominal) (8.53±2.83, 24.6±10.3 and 74.4±11.9 mg/m3
(analytical)). All animals were examined at the end of the chamber
equilibration period, at 0.25, 0.5, and 1h during exposure, at 0, 1, 2
and 24 h post exposure and twice daily during the 14-day post-exposure
observation period for those animals not sacrificed 24 h post exposure.
Body weights were recorded daily from pretreatment until sacrifice.
There were no unscheduled deaths. There were no effects on body weight
or body weight gain. The larynx showed treatment-related
histopathological findings in rats in the 74.4-mg/m3 exposure level
group. Based on the results of this study, the LC50 of BF3 was higher
than 74.4+/-11.9 mg/m3 when male and female rats were exposed for a
single, 4-hour period.
Quite similar LC50 ranges were reported in other publications: LC50 (4 h) of 1180 mg/m3 (Kasparov et al. 1972) and LC50 (1 h) of 899.34 -1439.56 mg/m3 (Vernot et al. 1977), indicating that the substance has a high potential of acute toxicity by inhalation.
The NOAEL for respiratory irritation following a single exposure of 4 hours to low dose levels was estimated around 24.6 mg/m3 (Rusch et al., 2008).
- Supporting / Read across to methanol:
The 4-hour LC50 of the read across substance methanol (CAS no. 67 -56 -1) in rats (via nose/head exposure) was calculated to be 128.2 mg/L (BASF, 1980b). For a 6 -hour exposure under the otherwise same conditions was calculated to be 87.5 mg/L. Clinical signs of toxicity were aqueous secretion of eyes and nose, labored breathing, staggering, apathy, and narcosis.
A similar range of toxicity values is reported for the mouse: LC50 (2.25 h) = approx. 79 mg/L (Von Burg, 1994).
In cats, a LC50 value of approx. 43.7 mg/L was obtained after a 6-hour exposure (Von Burg, 1994). A shorter duration of 4.5 hours led to a LC50 value of 85.4 mg/L (Von Burg, 1994).
Studies in Rhesus monkeys indicate lethal concentrations (% mortality not reported) of 1.3 mg/L (after 41 hours), 13 mg/L (after 18 hours) and 52 mg/L methanol (after 1–4 hours). Blindness associated with optic nerve atrophy was reported. Eventual recovery from this lesion was observed (McCord, 1931; only limited documentation).
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Legal classification regarding acute
toxicity is available for the read across substances boron trifluoride
and methanol:
Classification, Labelling, and Packing Regulation (EC) No. 1272/2008,
Table 3.1 List of harmonised classification and labelling of hazardous
substances:
- boron trifluoride: Acute Tox. 2 (H330: Fatal if inhaled)
- methanol: Acute Tox. 3 (H301 + H311 + H331: Toxic if swallowed, in
contact with skin or if inhaled)
[ Separate legal classification of boron
trifluoride dihydrate (CAS 13319-75-0) is not available.]
Considering legal classification and study results, the complex of boron
trifluoride with methanol should be classified with respect to acute
toxicity as follows:
Based on the legal classification under
Regulation (EC) No. 1272/2008 of the read across substances boron
trifluoride and methanol and the experimental data available for boron
trifluoride methanol, methanol, and boron trifluoride dihydrate, the
following classification and labelling is proposed for the test
substance:
Acute Tox. 3 (H311 + H331): Toxic in contact with skin and if inhaled
Acute Tox. 4 (H302): Harmful if swallowed
under Regulation (EC) No 1272/2008, as amended for the sixth time in
Regulation EC No 605/2014.
In addition, the legal classification as STOT SE cat. 1 for methanol is adopted.
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