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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Six groups of 10 male young adult rats (160-180 g) were dosed at 1000, 3100, 4000, 5000, 6300 or 8200 mg/kg bw. The animals were observed for mortality, body weights, clinical signs and gross pathological changes through day 14.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
m-phenylene di(acetate)
EC Number:
203-596-2
EC Name:
m-phenylene di(acetate)
Cas Number:
108-58-7
Molecular formula:
C10H10O4
IUPAC Name:
3-(acetyloxy)phenyl acetate

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
1000, 3100, 4000, 5000, 6300 or 8200 mg/kg bw
No. of animals per sex per dose:
Ten male animals per dose
Control animals:
no
Statistics:
Ld50 was calculated according to Fink and Hund, Arzneim.-forsch. 15, 624 (1965).

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
4 010 mg/kg bw
Based on:
test mat.
Mortality:
0% (1000 mg/kg bw), 30% (3100 mg/kg bw), 50% (4000 mg/kg bw), 60% (5000 mg/kg bw), 90% (6300 mg/kg bw), 100% (8300 mg/kg bw).
Clinical signs:
other: Clinical signs at 3100 mg/kg bw and above included tremor and bloody eyes.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD50 = 4010 mg/kg bw (rat, male).
Executive summary:

Six groups of 10 male young adult rats (160-180 g) were dosed at 1000, 3100, 4000, 5000, 6300 or 8200 mg/kg bw by gavage. The animals were observed for mortality, body weights, clinical signs and gross pathological changes through day 14. A LD50 = 4010 mg/kg bw was found.