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EC number: 260-789-4 | CAS number: 57526-50-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Initiation: March 01, 1983 - Termination: March 15,1983.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study; no data on TS purity reported
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 12 May 1982
- GLP compliance:
- no
Test material
- Reference substance name:
- Octahydro-4,7-methano-1H-indene-5-methanol
- EC Number:
- 260-789-4
- EC Name:
- Octahydro-4,7-methano-1H-indene-5-methanol
- Cas Number:
- 57526-50-8
- Molecular formula:
- C11H18O
- IUPAC Name:
- {tricyclo[5.2.1.0²,⁶]decan-8-yl}methanol
- Test material form:
- liquid
- Details on test material:
- Hoechst 1983
Constituent 1
- Specific details on test material used for the study:
- No information about purity. However, as it is stated in the section 13, the substance and its composition have remained essentially the same over the last decades.
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund, conventional breeding
- Weight at study initiation: 1.7 - 1.8 kg (3 animals)
- Housing: individual cages in fully air-conditioned rooms
- Diet: feed for breeding rabbits ERKA Z 6000, ad libitum
- Water: deionized chlorinated water, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2 °C
- Humidity (%): 55 +/- 10 %
- Photoperiod (hrs dark / hrs light): 12 hours per day
Test system
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: yes, the untreated right eye
- Amount / concentration applied:
- Concentration: 100 %
Amount applied: 0.1 ml - Duration of treatment / exposure:
- 24 hour(s)
- Observation period (in vivo):
- 14 days with readings after 1, 24, 48, 72 hours and 7 and 14 days post application
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: with physiological saline at 37°C
- Time after start of exposure: 24 h after application
SCORING SYSTEM: Draize (see guideline)
TOOL USED TO ASSESS SCORE: 0.01% fluorescein sodium solution and UV light (24 and 72 h post application)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.22
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.55
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.66
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- probability of weak irritation
Any other information on results incl. tables
RS-Freetext:
The individual effects of the rabbit eye were scored as follows:
Rabbit 1/2/3; 1h - 24hrs - 48 hrs - 72hrs - 7d -
14d
_______________________________________________
-Cornea:
1/1/1 - 1/1/2 - 1/1/2 - 0/1/2 - 0/1/2 - 0/0/1
-Iris
1/1/1 - 1/1/1 - 0/0/1 - 0/0/1 - 0/0/0 - 0/0/0
-Conjunctivae
Redness:
1/3/3 - 3/2/2 - 1/1/2 - 0/2/2 - 0/1/0 - 0/0/1
Chemosis:
1/2/2 - 2/2/1 - 1/2/1 - 0/1/2 - 0/0/1 - 0/0/0
_______________________________________________
The means of the effects were as follows:
24 hrs 48 hrs 72 hrs
________________________________________
cornea 1.33 1.33 1.0
iris 1.0 0.33 0.33
Conjunc.
redness 2.33 1.33 1.33
chemosis 1.67 1.33 1.0
________________________________________
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- CL-Freetext:
The TS caused moderate eye irritation in all animals.
The effects were reversible and were absent in two animals at 14 days after treatment. Cornea opacity and conjunctivae redness grade 1 persisted in one animal until the end of the observation period, however, the effects were less severe than after the beginning of the observation period. As it can reasonably be assumed, that the effects would have been fully reversible, if the observation period would have been extended to 21 days, it is concluded that the substance is irritating to the eyes (GHS Cat. 2A).
- Executive summary:
Eye irritating effects have been investigated in rabbits according to OECD TG 405. At the end of the treatment period cornea opacity, as well as effects on the iris, and conjunctivae were observed (mean values after 24 -48 -72 hours for all three animals: 1.22, 0.55, 1.66 and 1.33, for cornea, iris, redness and chemosis, respectively). The effects were reversible and were absent in two animals at 14 days after treatment. Cornea opacity and conjunctivae redness grade 1 persisted in one animal until the end of the 14 day observation period, however, the effects were less severe than after the beginning of the observation period.
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