Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 947-646-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1st September 2015 - 15th December 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: A well conducted study according to guideline and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction Mass of Mixed Xylenes and Sulphur Monochloride
- IUPAC Name:
- Reaction Mass of Mixed Xylenes and Sulphur Monochloride
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No. of test material: Batch 46000058
- Purity test date: Not applicable; substance is a UVCB
OTHER SPECIFICS:
Due to the low water solubility of the test item, a modification to the standard method of preparation for aqueous media was performed. The organisms were exposed to a Water Accommodated Fraction (WAF), as accepted by many regulatory authorities in the EU (ECETOC 1996, OECD 2000 and Singer et al 2000). Aqueous media are prepared by mixing test item with water for a prolonged period, the solution is left to settle and the test item phase siphoned off. The test organisms are exposed to the aqueous phase or WAF, containing dissolved test item and leachates from the test item. Exposure is expressed in terms of the original concentration of test item in water at the start of the mixing period irrespective of the dissolved fraction.
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Water samples were taken from the test solution at 0 and 48 hours for quantitative analysis
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- An amount of test material (200 mg) was added to the surface of 2 litres of test water to give 100mg/L loading rate. The Water Accommodated Fraction (WAF) was prepared over 23 hours. The WAF removed from mid-depth.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Source:Envigo Research Limited in-house laboratory cultures.
- Age at study initiation (mean and range, SD): < 24hours
ACCLIMATION
- Acclimation period: Not relevant
- Type and amount of food: Daily Algal suspension (Desmodesmus subspicatus) and Tetramin flake food.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 21 - 22°C
- pH:
- 8.0-8.1
- Dissolved oxygen:
- 8.8 - 8.9 mg O2/l
- Nominal and measured concentrations:
- Nominal concentration 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 250 ml glass jar
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates):4
- No. of vessels per control (replicates): 4 - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mobility
- Details on results:
- The cumulative immobilisation data and observations made in the definitive test are presented in tables 1 and 2 below.
Table 1. 24 hour data
Cumulative Immobilised Daphnia
Nominal Loading Rate (mg/L) (Initial population: 5 per replicate) Observations
R1 R2 R3 R4 Total % R1 R2 R3 R4
Control 0 0 0 0 0 0 5 N 5 N 5 N 5 N
100 0 0 0 0 0 0 5 N 5 N 5 N 5 N
Table 2. 48 hour data
Cumulative Immobilised Daphnia
Nominal Loading Rate (mg/L) (Initial population: 5 per replicate) Observations
R1 R2 R3 R4 Total % R1 R2 R3 R4
Control 0 0 0 0 0 0 5 N 5 N 5 N 5 N
100 0 0 0 0 0 0 5 N 3 N,2T 2 N, 3T 3 N, 2T
R1 –R4: Replicates 1 -4
N: No sub-lethal effects observed
T: Trapped at surface
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48 hour EL50 of 'Reaction mass of mixed xylenes and sulphur monochloride' in Daphnia magna was >100mg/L mg/l. The NOELR was 100 mg/l.
- Executive summary:
A GLP study was performed to assess the acute toxicity of 'Reaction mass of mixed xylenes and sulphur monochloride' to Daphnia Magna in accordance with OECD 202. Following a preliminary range-finding study, twenty daphnids (4 replicates of 5 animals) were exposed to aqueous dispersions of the test substance at concentrations of 0 and 100 mg/l for 48 hours under static test conditions. The numbers of immobilised Daphnia were recorded after 24 and 48 hours.
From the results of the test, the 48 hour EL50 for the test material was determined to be > 100 mg/L, based on nominal test concentrations. The No Observed Effect Loading Rate was 100 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.