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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
pH
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Cross-reference
Reason / purpose for cross-reference:
reference to same study
Reference

Two studies were performed to assess the skin and eye irritancy potential of the 4,4'-Benzylidenedianiline in the New Zealand White rabbit, according to the OECD guidelines 404 and 405 and EC Regulation methods B4 and B5, accordingly.

None of the applications to the rabbit intact skin produced any evidence of skin irritation.

A single application of the test material to the non-irrigated eye of two rabbits produced moderate conjunctival irritation but treated eyes appeared normal at the 48-hour observation.

It can be concluded that 4,4'-Benzylidenedianiline is not irritant to the skin but mildly irritant for the eyes.

The test item is not classified according to CLP criteria for skin and eye irritation.

Endpoint conclusion:
no adverse effect observed (not irritating)
Endpoint conclusion:
no adverse effect observed (not irritating)

The test item is not classified for skin and eye irritation according to CLP criteria.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD TG 404
GLP compliance:
yes

Results and discussion

pH valueopen allclose all
Key result
pH value:
8.9
Concentration:
10 other: % w/w
Remarks on result:
other: measured immediately
Key result
pH value:
9.4
Concentration:
10 other: %w/w
Remarks on result:
other: measured after 10 minutes
Key result
pH value:
9.5
Concentration:
10 other: %w/w
Remarks on result:
other: measured after 20 minutes

Applicant's summary and conclusion

Conclusions:
pH of 4,4'-Benzylidenedianiline in 10% w/w water has been measured in OECD TG 404 test as 8.9 (immediately), 9.4 (after 10 mintes) and 9.5 (after 20 minutes).
Executive summary:

pH of 4,4'-Benzylidenedianiline in 10% w/w water has been measured in OECD TG 404 test as 8.9 (immediately), 9.4 (after 10 mintes) and 9.5 (after 20 minutes).