Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-626-4 | CAS number: 108-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: case reports
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Anecdotal reports of effects of exposure of methyl pyridines.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- 3-Methylpyridine: Human toxicity excerpts
- Author:
- Anonymous
- Year:
- 2 010
- Bibliographic source:
- Hazardous Substances Data Base(HSDB), ToxNet, http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~rYtOpf:1
Materials and methods
- Study type:
- other: case reports
- Endpoint addressed:
- not applicable
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- case reports of exposures
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-methylpyridine
- EC Number:
- 203-626-4
- EC Name:
- 4-methylpyridine
- Cas Number:
- 108-89-4
- Molecular formula:
- C6H7N
- IUPAC Name:
- 4-methylpyridine
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not applicable
- Reason of exposure:
- unintentional, occupational
- Exposure assessment:
- not specified
Results and discussion
Any other information on results incl. tables
4-METHYLPYRIDINE
CASRN: 108 -89 -4
For other data, click on the Table of Contents
Human Toxicity Excerpts:
CLINICAL SIGNS OF INTOXICATION CAUSED BY ALKYL DERIV OF PYRIDINE INCL WT
LOSS, DIARRHEA, WEAKNESS, ATAXIA & UNCONSCIOUSNESS. /PYRIDINE ALKYL
DERIV/
[International Labour Office.
Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva,
Switzerland: International Labour Office, 1983., p. 1811] **PEER
REVIEWED**
Exposures to the picolines may give rise to flushing of the face, skin
rash, an incr in heart & respiration rates, headache, giddiness, nausea
& vomiting. /Picolines/
[International Labour Office.
Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva,
Switzerland: International Labour Office, 1983., p. 1577] **PEER
REVIEWED**
Data indicates that 4-methylpyridine is moderately toxic when
administered orally & very toxic when given dermally & ip. Symptoms
include occasional diarrhea, weight loss, anemia, & ocular & facial
paralysis.
[Snyder, R. (ed.). Ethyl Browning's
Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II:
Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier,
1990., p. 235] **PEER REVIEWED**
4-Methylpyridine induced a dose-related increased frequency of sister
chromatid exchange in human lymphocyte cultures from three individuals.
Chromosomal aberrations induced by 4-methylpyridine included: chromatid
breaks; centromeric, intermediate & terminal chromosome breaks; terminal
& interstitial deletions; translocation; dicentric chromosomes; &
isochromosomes.
[Snyder, R. (ed.). Ethyl Browning's
Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II:
Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier,
1990., p. 235] **PEER REVIEWED**
ALKYL DERIVATIVES, PICOLINES ... CAUSE SYMPTOMS RESEMBLING THOSE
OBSERVED WITH PYRIDINE. THESE ARE LARGELY NONSPECIFIC & INCL WEAKNESS,
ATAXIA, DIARRHEA, & UNCONSCIOUSNESS. DELAYED DEATHS FOLLOWING SINGLE
DOSE ARE UNCOMMON & SURVIVORS GENERALLY GAIN WT NORMALLY. /PICOLINES/
[Clayton, G. D. and F. E. Clayton
(eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C:
Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2724]
**PEER REVIEWED**
Skin, Eye and
Respiratory Irritations:
Pyridine and its derivatives cause local irritation on
contact with the skin, mucous membranes and cornea. /Pyridine and its
derivatives/
[International Labour Office.
Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva,
Switzerland: International Labour Office, 1983., p. 1810] **PEER
REVIEWED**
A severe skin & eye irritant.
[Lewis, R.J. Sax's Dangerous Properties
of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand
Reinhold, 1996., p. 2305] **PEER REVIEWED**
Applicant's summary and conclusion
- Conclusions:
- CLINICAL SIGNS OF INTOXICATION CAUSED BY ALKYL DERIV OF PYRIDINE INCLUDE WEIGHT LOSS, DIARRHEA, WEAKNESS, ATAXIA & UNCONSCIOUSNESS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.