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Diss Factsheets
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EC number: 218-465-5 | CAS number: 2157-01-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Data from secondary source (peer-reviewed handbook). The data are reported to be unpublished, original data of the author (Fasset) from the Laboratory of Industrial Medicine, Eastman Kodak Co., Rochester NY Insufficient information to determine reliability
- Justification for type of information:
- Read across from the 2 Ethylhexyl methacrylate category member donor substance.
REPORTING FORMAT FOR THE CATEGORY APPROACH
see attached category document
PM_Lower Alkyl (C1-C8) Methacrylates
This is a category (C1-C8 Lower Alkyl Methacrylates) with clear trends in the physicochemical properties of its members, related to molecular weight, molecular size and hydrophilicity.
There are only limited acute dermal toxicity data for the members of the category C1-C8 Lower Alkyl Methacrylates available. Guideline studies are only available for MMA and nBMA. There are reliable data for MMA and nBMA indicating that these esters are of low acute dermal toxicity. There are also two early pre-guideline studies of limited reliability available in guinea pigs for i-BMA and 2-EHMA that indicate low acute dermal toxicity and although there is no fully valid study for 2-EHMA, the upper bound of the category, there is a trend of decreasing skin absorption across the category (see section 5.1) indicating that the acute dermal toxicity of all members will be equally low. This is supported by the observation that the members are all of low acute oral toxicity.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 963
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: not known
- Principles of method if other than guideline:
- other
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Octyl methacrylate
- EC Number:
- 218-465-5
- EC Name:
- Octyl methacrylate
- Cas Number:
- 2157-01-9
- Molecular formula:
- C12H22O2
- IUPAC Name:
- octyl 2-methylprop-2-enoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 20 mL/kg bw
- Remarks on result:
- other: 17620 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- A published LD50 >20 ml/kg bw in guinea pigs is available.
- Executive summary:
A published LD50 >20 ml/kg bw in guinea pigs is available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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