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EC number: 203-694-5 | CAS number: 109-67-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: Not irritating (EU Method B4, Rel.2, K).
Eye irritation: Not irritating (EU Mehod B5, Rel. 2, K).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12.7.1982-26.7.1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Fully documented, non GLP Study.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- No stepwise approach was adopted. Only the average weight of the test animals is given, and not the weight at the beginning and end of the test.
- Principles of method if other than guideline:
- In addition to the stated guideline, the test substance was applied to damaged skin to investigate systemic effects.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: Russian (Albino)
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Asta-Werke AG, D-4800 Bielefeld 14
- Age at study initiation: 10 - 11 months
- Weight: 2.7 - 2.9 kg
- Housing: single
- Diet (e.g. ad libitum): Standardized feed for test animals ALTROMIN
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 1 days
- gender: female
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 1°C
- Humidity (%): 50 - 60 %
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): 12h/12h - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Observation after 1, 24, 48 and 72 hours
- Number of animals:
- 3 female animals tested
- Details on study design:
- TEST SITE
- Area of exposure:
- % coverage: 100%
- Type of wrap if used: 6.25cm2 linen piece, covered by a synthetic self-adhesive strip; subsequently the patches were covered by a bandage (acrylastic)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
SCORING SYSTEM:
Values for erythema and eschar formation as well as oedema formation were averaged for all animals and summed up. The sum resulted from 16 averages and was divided by 8 to obtain the primary irritation index:
0.0 - 0.5: non irritating
0.6 - 3.0: slightly irritating
3.1 - 5.0: moderately irritating
5.1 - 8.0: strongly irritating - Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- # animals 1-3; intact and scarified skin
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable as no effect
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- #animals 1-3; intact and scarified skin
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable as no effect
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No erythema or oedema formation was observed on any of the test animals at any observation time. Merely horny skin callus developed on the intact and scarified skin in the second observation period.
- Other effects:
- No systemic toxicity effects were observed after dermal application of the product.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the test conditions, 1-pentene is not classified for skin irritation according to the Annex I of the Regulation (EC) No. 1272/2008 (CLP) and to the GHS.
- Executive summary:
In a dermal irritation study performed similarly to the EU Method B4, 0.5 mL of test material was applied on intact and scarrified skin of 3 female Russian rabbits. Test sites were covered with an occlusive dressing for 4 hours. Skin irritation was assessed and scored according to the Draize scale at 1, 24, 48 and 72 h after the removal of the patch.
No reaction on intact or scarrified skin was found. The animals did not show any clinical signs during the course of the study and no cases of mortality were observed.
The individual scores for each animal within 3 scoring times (24, 48 and 72 h) were 0.0 / 0.0 / 0.0 for erythema and oedema.
Based on the available data, the test item Pentene-1 was not skin irritant. No additional self-classification is proposed regarding skin irritation according to the Annex I of the Regulation (EC) No. 1272/2008 (CLP) and to the GHS.
This study is considered as acceptable and satisfies the requirement for skin irritation endpoint.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16.07.1982 - 06.08.1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Fully documented, non GLP Study.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- The stepwise approach from the guideline is not adopted. Only the average weight of the test animals is given, and not the weight at the beginning and end of the test.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: Russian Albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Asta-Werke AG, D-4800 Bielefeld 14
- Age at study initiation: not reported
- Weight: 2.6 - 2.9 kg
- Housing: single
- Diet (e.g. ad libitum): Standardized feed for test animals ALTROMIN
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 1 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 1°C
- Humidity (%): 50 - 60 %
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): 12h/12h - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- The lids were gently held together for about one second in order to prevent loss of the material. No further indication on the exposure time was reported
- Observation period (in vivo):
- 1, 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- 3 Female animals
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): No
SCORING SYSTEM:
Eye changes were scored according to standard method (EU B.5.). The scores were multiplied, averaged and added according to a predefined scheme resulting in an irritation index (Draize, J.H., Woodward, G. and H.O.Calvery, J. Pharmacol. Exp. Therap., 82, 377-390, 1944 and Draize, J.H. in Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics; 46-59, Assoc. of Food and Drug Officials of the United States, Topeka, Kansas (1965)):
0-10 not irritating
11-25 slightly irritating
26-56 moderately irritating
57-110 strongly irritating
TOOL USED TO ASSESS SCORE: hand-slit lamp (model: ophthalmoskop, Fa. Heine, Type med. 261) - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- animals 1-3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable as no effect
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- animals 1-3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable as no effect
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable as no effect
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable as no effect
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Only short-term changes of low intensity were induced upon insertion of 1-pentene into the rabbit eye. Cornea and Iris were without reaction upon contact. The conjunctiva reacted with redness, swelling and secretion. Redness consisted of the formation of slight hyperemia with a grade of 1. They appeared for all 3 animals up to 72 h. One animal showed a slight swelling which had disappeared after 48 h. Secretion was only observed for 2 animals. This finding was observed only for 1 hour after application. The intensity reached a grade of 2.
- Other effects:
- Systemic toxicity effects were not observed.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the test conditions, the test material is not classified as irritating to eyes according to the criteria of the Annex I of the Regulation (EC) No. 1272/2008 (CLP) and to the GHS.
- Executive summary:
In an eye irritation study performed similarly to the EU Method B5, 0.1 mL of undiluted test material was instilled into one eye of 3 female Russian rabbits. The upper and lower eyelids were held together for about one second immediately after application, to prevent loss of the test material, and then released. The eyes were examined and the changes were observed at 1, 24, 48 and 72 h after treatment and graded according to the Draize method.
Only the conjunctiva showed low-grade changes.
The conjunctiva reacted short-term (after 1 hour) with redness, swelling and secretion. 48 h after application only slight hyperamia was observed which was declining immediately after the 72h-observation phase.
Mean individual scores at 24, 48 and 72 h after exposure for the 3 animals were 0.0 / 0.0 / 0.0 for cornea and iris scores; 1.0 / 1.0 / 1.0 for conjunctivae score and 0.0 / 0.3 / 0.0 for chemosis score.
Under the test conditions, the test material is not classified as irritating to eyes according to the criteria of the Annex I of the Regulation (EC) No. 1272/2008 (CLP) and to the GHS.
This study is considered as acceptable and satisfies the requirement for eye irritation endpoint.
Reference
Table 7.3.2/1: Effects of 1-pentene on the conjunctiva of rabbit eyes (values for cornea and iris were 0 in all cases)
exposition time (h) | reaction grade according to Draize | |||
Animal No | 1 | 2 | 3 | |
redness | 1 | 1 | 1 | 1 |
24 | 1 | 1 | 1 | |
48 | 1 | 1 | 1 | |
72 | 1 | 1 | 1 | |
swelling | 1 | 0 | 1 | 0 |
24 | 0 | 1 | 0 | |
48 | 0 | 0 | 0 | |
72 | 0 | 0 | 0 | |
secretion | 1 | 1 | 2 | 0 |
24 | 0 | 0 | 0 | |
48 | 0 | 0 | 0 | |
72 | 0 | 0 | 0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
A key study was identified (ASTA-WERKE AG, 1982b, rel. 2). This dermal irritation study was performed similarly to the EU Method B4.
No evidence of skin irritation was observed in intact and abraded skins following a 4 -hour exposure period under an occlusive dressing.
The individual scores for each animal within 3 scoring times (24, 48 and 72 h) were 0.0 / 0.0 / 0.0 for erythema and oedema.
Eye irritation:
A key study was identified (ASTA-WERKE AG, 1982c, rel.2). This eye irritation study was performed similarly to the EU Method B5.
No corneal or iridial effects were observed during the study.
Only the conjunctiva showed low-grade changes. The conjunctiva reacted short-term (after 1 hour) with redness, swelling and secretion. 48 h after application only slight hyperamia was observed which was declining immediately after the 72h-observation phase.
Mean individual scores at 24, 48 and 72 h after exposure for the 3 animals were 0.0 / 0.0 / 0.0 for cornea and iris scores; 1.0 / 1.0 / 1.0 for conjunctivae score and 0.0 / 0.3 / 0. for chemosis score.
Justification for classification or non-classification
Harmonized classification:
The substance has no harmonized classification according to the Regulation (EC) No. 1272/2008.
Self classification:
Based on the available data, no additional self-classification is proposed for the registered substance regarding skin and eye irritation according to the Annex I of the Regulation (EC) No. 1272/2008 (CLP) and to the GHS.
No data was available regarding respiratory irritation. Not required for substances at the REACH Annex VII tonnage level.
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