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EC number: 220-744-1 | CAS number: 2885-00-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- Results are based on octanethiol which is a shorter alkyl chain version of octadecylmercaptan. As the thiol/mercaptan group is the active functional group then any toxic effects will specifically be due to the terminal thiol/mercaptan group. The alkyl chain just affects the water solubility and does not play a significant biochemical role or toxicological role. That is why the C8 thiol is a very good analogue for the longer chain thiol/mercaptan.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Octane-1-thiol
- EC Number:
- 203-918-1
- EC Name:
- Octane-1-thiol
- Cas Number:
- 111-88-6
- Molecular formula:
- C8H18S
- IUPAC Name:
- octane-1-thiol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Rearing automatically controlled at a temperature of 22 ± 2 ° C., relative humidity of 55 ± 15%, ventilation at about 12 times / hour, lighting 12 hours / day (7: 00-19: 00) I used.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on exposure:
- Daily exposure for 35 days total.
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 35 days
- Frequency of treatment:
- Daily
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 mg/kg bw/day (actual dose received)
- Dose / conc.:
- 10 mg/kg bw/day (actual dose received)
- Dose / conc.:
- 50 mg/kg bw/day (actual dose received)
- Dose / conc.:
- 250 mg/kg bw/day (actual dose received)
- No. of animals per sex per dose:
- 12 females per dose level
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- For the administration period, the males were taken for a total of 35 days before the mating and for the mating period up to the day before the autopsy, the females were for 14 days before the mating, the mating period, the gestation period and the 4 days after the birth via the parturition. Females who did not mate and females that did not deliver were taken until the day before necropsy. At the time of administration, it was administered by gavage once a day using the teflon stomach probe, in the morning. The volume of solution administered was 2 mL / kg, and it was calculated based on the body weight measured on the nearest day.
- Positive control:
- None
Examinations
- Parental animals: Observations and examinations:
- Observations made at 0, 3, 7, 14, 21, 28 and 34 days test duration for males
Observations made at 0, 3, 7, 14 prior to mating; 0, 7, 14, 20 gestation period and 0, 4 days lactation period for females - Oestrous cyclicity (parental animals):
- 3.98 up to 4.36 from 0 to 250mg/kg bw dosing.
- Sperm parameters (parental animals):
- No effects observed.
- Litter observations:
- No change due to the test substance was observed in the examination of neonates in any of the number of births, the number of babies born, sex ratio, birth rate, 4 day survival rate of neonates, external table, general condition, weight and autopsy.
- Postmortem examinations (parental animals):
- In the 250 mg / kg group, a significant lower value of the gestation period extension and delivery rate was observed. In addition, no change was observed in the test substance administered group for the number of corpus luteums, the number of implantation, the implantation rate and the birth rate. In addition, abnormalities in labor condition and nursing behavior were not observed.
No abnormality was found in any of the 10 and 50 mg / kg groups. - Postmortem examinations (offspring):
- No change due to the test substance was observed in the examination of neonates in any of the number of births, the number of babies born, sex ratio, birth rate, 4 day survival rate of neonates, external table, general condition, weight and autopsy.
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- no effects observed
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- mortality observed, non-treatment-related
- Description (incidence):
- 1 death but not attributed to administration.
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
Reproductive function / performance (P0)
- Reproductive function: oestrous cycle:
- no effects observed
- Reproductive function: sperm measures:
- not specified
- Reproductive performance:
- no effects observed
Effect levels (P0)
open allclose all
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- >= 250 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- clinical signs
- mortality
- body weight and weight gain
- organ weights and organ / body weight ratios
- gross pathology
- reproductive function (oestrous cycle)
- reproductive performance
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- >= 250 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- clinical signs
- gross pathology
- reproductive function (oestrous cycle)
- reproductive performance
Results: P1 (second parental generation)
General toxicity (P1)
- Clinical signs:
- no effects observed
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
Reproductive function / performance (P1)
- Reproductive function: oestrous cycle:
- not specified
- Reproductive function: sperm measures:
- not specified
- Reproductive performance:
- not specified
Results: F1 generation
General toxicity (F1)
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality / viability:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings:
- not specified
Developmental neurotoxicity (F1)
- Behaviour (functional findings):
- not specified
Developmental immunotoxicity (F1)
- Developmental immunotoxicity:
- not specified
Effect levels (F1)
- Key result
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- >= 250 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- viability
- clinical signs
- mortality
- body weight and weight gain
- gross pathology
Overall reproductive toxicity
- Key result
- Reproductive effects observed:
- no
- Lowest effective dose / conc.:
- 250 mg/kg bw/day (actual dose received)
- Treatment related:
- no
Any other information on results incl. tables
The result of 250mg/kg bw for reproductive toxicity is based on interpretation of the paper. The result of a slight increase in gestation cycle and decrease in the pup viabiliy ratio are within the statistical parameters of the test background parameters so the quoted 50 mg/kg bw value for NOAEL is considered too harsh compared to the statistics of the test results.
Applicant's summary and conclusion
- Conclusions:
- The NOAEL on reproductive and developmental toxicity was 250 mg / kg / day in male parent animals, 250 mg / kg / day for female parent animals and 250 mg / kg / day in pediatric animals.
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