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Diss Factsheets
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EC number: 208-654-0 | CAS number: 537-00-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 July 2017 to 27 July 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: European Commission Technical Guidance Document EUR 20268 'Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances’
- Version / remarks:
- 2002
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- cascade impaction
- Type of particle tested:
- primary particle
- Type of distribution:
- mass based distribution
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- 41.1 %
- No.:
- #2
- Size:
- < 10 µm
- Distribution:
- 0.884 %
- No.:
- #3
- Size:
- < 5.5 µm
- Distribution:
- 0.191 %
- Conclusions:
- Under the conditions of the study the percentage of test material with an inhalable particle size <100 μm was 41.1 %, the percentage of test material with a thoracic particle size <10.0 μm was 0.884 % and the percentage of test material with a respirable particle size <5.5 μm was 0.191 %.
- Executive summary:
The particle size distribution of the test material was determined in accordance with the European Commission Guidance Document EUR 20268 ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances’ (2002), under GLP conditions using the sieving method and cascade impactor.
In the sieving screening test an aliquot (18.76 g) of test material was added to a 100 μm sieve fitted onto a receiver pan of known mass. The percentage of test material having an inhalable particle size of less than 100 μm was determined to be 41.1 % in the screening test.
Sampling for the cascade impactor determinations was performed by rolling the test material container for approximately 10 minutes then sampling it from the top, middle and bottom. The overall results from the cascade impactor were taken as limit values due to the variation between the sampling positions; this gives a worst case scenario. Too few particles were of a size less than 10.0 μm to allow accurate assessment of the mass median aerodynamic diameter. The inhalable fraction is defined as the mass fraction of particles which can be inhaled by nose or mouth, the thoracic fraction is defined as the mass fraction of particles that passes the larynx and the respirable fraction is defined as the mass fraction of particles that reaches the alveoli.
Under the conditions of the study the percentage of test material with an inhalable particle size <100 μm was 41.1 %, the percentage of test material with a thoracic particle size <10.0 μm was 0.884 % and the percentage of test material with a respirable particle size <5.5 μm was 0.191 %.
Reference
Table 2: Table to show the results of the sieving procedure
Measurement |
Result |
Mass of test material transferred to sieve (W1) |
18.67 g |
Mass of test material passed through sieve (W3 – W2) |
7.67 g |
Percentage of test material less than 100 μm |
41.1 % |
Table 3: Table to show the cumulative amounts of test material collected in the three determinations for the individual particle size cut-points in the cascade impactor.
Particle Size Cut Points (µm) |
Cumulative mass (g) |
Cumulative Percentage (%) |
||||
Determination 1 |
Determination 2 |
Determination 3 |
Determination 1 |
Determination 2 |
Determination 3 |
|
<10.0 |
0.0356 |
0.0199 |
0.0243 |
1.21 |
0.649 |
0.796 |
<5.5 |
0.0078 |
0.0039 |
0.0055 |
0.265 |
0.127 |
0.180 |
<2.4 |
0.0029 |
0.0014 |
0.0019 |
0.098 |
0.046 |
0.062 |
<1.61 |
0.0007 |
0.0001 |
0.0002 |
0.024 |
0.003 |
0.007 |
<0.307 |
0.0000 |
0.0001 |
0.0000 |
0.000 |
0.003 |
0.000 |
Table 4: Summary of Results
Measurement |
Method |
Result |
Percentage of test material with an inhalable particle size <100 μm |
Sieve |
41.1 % |
Percentage of test material with a thoracic particle size <10.0 μm |
Cascade Impactor |
0.884 % |
Percentage of test material with a respirable particle size <5.5 μm |
Cascade Impactor |
0.191 % |
- Sampling for the cascade impactor determinations was performed by rolling the test material container for approximately 10 minutes then sampled from the top, middle and bottom. The overall results from the cascade impactor were taken as limit values due to the variation between the sampling positions; this gives a worst case scenario. Too few particles were of a size less than 10.0 μm to allow accurate assessment of the mass median aerodynamic diameter
- The inhalable fraction is defined as the mass fraction of particles which can be inhaled by nose or mouth, the thoracic fraction is defined as the mass fraction of particles that passes the larynx and the respirable fraction is defined as the mass fraction of particles that reaches the alveoli.
Description of key information
Fox (2017)
Under the conditions of the study the percentage of test material with an inhalable particle size <100 μm was 41.1 %, the percentage of test material with a thoracic particle size <10.0 μm was 0.884 % and the percentage of test material with a respirable particle size <5.5 μm was 0.191 %.
Additional information
Fox (2017)
The particle size distribution of the test material was determined in accordance with the European Commission Guidance Document EUR 20268 ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances’ (2002), under GLP conditions using the sieving method and cascade impactor. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
In the sieving screening test an aliquot (18.76 g) of test material was added to a 100 μm sieve fitted onto a receiver pan of known mass. The percentage of test material having an inhalable particle size of less than 100 μm was determined to be 41.1 % in the screening test.
Sampling for the cascade impactor determinations was performed by rolling the test material container for approximately 10 minutes then sampling it from the top, middle and bottom. The overall results from the cascade impactor were taken as limit values due to the variation between the sampling positions; this gives a worst case scenario. Too few particles were of a size less than 10.0 μm to allow accurate assessment of the mass median aerodynamic diameter. The inhalable fraction is defined as the mass fraction of particles which can be inhaled by nose or mouth, the thoracic fraction is defined as the mass fraction of particles that passes the larynx and the respirable fraction is defined as the mass fraction of particles that reaches the alveoli.
Under the conditions of the study the percentage of test material with an inhalable particle size <100 μm was 41.1 %, the percentage of test material with a thoracic particle size <10.0 μm was 0.884 % and the percentage of test material with a respirable particle size <5.5 μm was 0.191 %.
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