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Diss Factsheets
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EC number: 279-242-6 | CAS number: 79720-19-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: expert statement
Reference
Description of key information
There are no studies available in which the toxicokinetic properties of the substance were investigated.
The test item is a clear, medium viscous and organic substance. It does not hydrolyse at pH 7, at pH 9 only a slow hydrolysis was observed (see IUCLID chapter 5.1.2). The water solubility is 6.3 mg/L (see IUCLID chapter 4.8). The octanol water partition coefficient (Log Pow) for the substance was determined to be greater than 5.7 (see IUCLID chapter 4.7). Due to the very limited water solubility a general potential of bioaccumulation can be excluded.
Absorption
With reference to the low solubility in water and its complex structure the absorption of the substance is considered to be restricted (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, Table R.7.12-1, p. 168). Furthermore, even if low amounts of the substance are dissolved in aqueous solutions it might dissociate into ionic species (i.e. N+). Ionisation does not contribute to a readily diffusion across biological membranes (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, p. 167). Therefore, an excessive absorption of the substance can be excluded. However, based on the results of several oral toxicity studies in rats (acute oral toxicity study: LD50 2000 mg/kg bw; 28 d oral toxicity: NOAEL 25 mg/kg bw/d) effects were observed especially in the course of the subacute study that prove the bioavailability of at least a small amount of the substance.
Distribution
The substance is only very limited water soluble. Therefore, it will not migrate into cells and concentrate in adipose tissues or other systemic compartments (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, pp. 176-177).
Metabolism
Taking into account the very limited water solubility and the results of several oral toxicity studies, a moderate uptake of this substance is considered to occur.
Studies on genotoxicity performed with the test item (Ames-Test; HPRT test and chromosome aberration test) were negative, i.e. there is no indication of a reactivity of the substance under the test conditions. With reference to its chemical composition and structure the cleavage of the carbonyl-nitrogen binding might be considered as possible metabolic pass way.
Excretion
With reference to the limited solubility the biliary excretion might be considered as the most favorable excretion route. Therefore, enterohepatic recycling resulting in a prolonged biological half-life can not be excluded (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, p. 178).
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
none
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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