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EC number: 223-672-9 | CAS number: 4016-14-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: in vivo, rabbit, Standard Draize test, 459 mg / 3d (RTECS): moderate reaction severity
Skin irritation: in vivo, rabbit, Standard Draize test, 100 mg / 24h (RTECS): moderate reaction severity
Skin irritation: Draize test, repeated 1h exposures (handbook): moderately irritating
Skin irritation: in vivo, California Albino or New Zealand White rabbit, semiocclusive, 0.5 mL (OECD 404): Draize score 4.3: moderately irritating
Eye irritation: in vivo, rabbit, Standard Draize test, 92 mg (RTECS): moderate reaction severity
Eye irritation: in vivo, rabbit, Standard Draize test, 20 mg / 24h (RTECS): moderately irritating
Eye irritation: in vivo (handbook): Draize score 40: moderately irritating
Eye irritation: in vivo, rabbit (handbook): moderately irritating
Eye irritation: in vivo, California Albino or New Zealand White rabbit, 0.1 mL (OECD 405): Draize score 40: moderately irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- other: publication
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Sufficiently documented publication, scientifically reasonable method, testing performed on the registered substance itself.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not applicable
- GLP compliance:
- no
- Remarks:
- conducted prior to GLP implementation
- Species:
- rabbit
- Strain:
- other: California Albino or New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: rabbitry at Point Reyes, Calif., or Gilroy laboratory, Calif.
- Weight at study initiation: 2 - 3 kg - Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped: scarified or intact
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- min. 24h, max. 72h, as there is no data on removal of test substance
- Number of animals:
- no data
- Details on study design:
- TEST SITE
- Area of exposure: back and flanks of rabbits were clipped 24 hours prior to use. The shoulders and hips were used as test sites, two areas on each animal being scarified and two intact.
- Type of wrap if used: patch consisting of three layers of gauze was secured over each area with adhesive tape, and 0.5 ml of the undiluted compound was introduced under the gauze. The rabbits were wrapped in towels.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: mean of 24h and 72h
- Score:
- 4.3
- Reversibility:
- no data
- Remarks on result:
- other: Scoring according to Draize (Draize JH: Procedures for the Appraisal of the Toxicity of Chemicals in Food, Drugs, and Cosmetics: VIII. Dermal Toxicity, Food, Drug, & Cos Law . 10:722, 1955)
- Irritant / corrosive response data:
- Moderate irritant
- Interpretation of results:
- other: moderately irritating (criteria used for interpretation of results: Draize scoring)
- Conclusions:
- The studied was conducted scientifically reasonable with sufficient documentation similar to OECD 404, it was assessed with Klimisch 2. Hence, the results are sufficiently reliable to assess the skin irritating properties of isopropyl glycidyl ether in rabbits. With an irritation score of 4.3, the substance is considered as moderate irritant according to Draize.
- Executive summary:
In a primary dermal irritation study similar to OECD 404, male California Albino or New Zealand White rabbits were
dermally exposed to 0.5 mL of unchanged Isopropyl glycidyl ether for 24 hours to the untreated or scarified skin of the hips and shoulders. Animals were observed for at least 72 hours. Irritation was scored by the method of Draize.In this study, Isopropyl glycidyl ether is a moderate dermal irritant.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- other: publication
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Sufficiently documented publication, scientifically reasonable method, testing performed on the registered substance itself.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not applicable
- GLP compliance:
- no
- Remarks:
- conducted prior to GLP implementation
- Species:
- rabbit
- Strain:
- other: California Albino or New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: rabbitry at Point Reyes, Calif., or Gilroy laboratory, Calif. - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated second eye
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- no information given on wash-out after instillation
- Observation period (in vivo):
- at least 48 h
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
SCORING SYSTEM: Draize - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: mean after 1, 24, 48 h
- Score:
- 40
- Reversibility:
- fully reversible
- Remarks on result:
- other: Scoring according to Draize (Draize JH: Procedures for the Appraisal of the Toxicity of Chemicals in Food, Drugs, and Cosmetics: VIII. Dermal Toxicity, Food, Drug, & Cos Law . 10:722, 1955)
- Interpretation of results:
- other: moderately irritating (criteria used for interpretation of results: Draize scoring)
- Conclusions:
- The studied was conducted scientifically reasonable with sufficient documentation similar to OECD 405, it was assessed with Klimisch 2. Hence, the results are sufficiently reliable to assess the eye irritating properties of isopropyl glycidyl ether in rabbits. With an irritation score of 40, the substance is considered as moderate irritant according to Draize.
- Executive summary:
In a primary eye irritation study similar to OECD 405, 0.1 mL of unchanged Isopropyl glycidyl ether was instilled into the eye of male California Albino or New Zealand White rabbits. Animals then were observed for at least 48 h. Irritation was scored by the method of Draize.
In this study, Isopropyl glycidyl ether is a moderate eye irritant.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There are four entries on skin irritation and five on eye irritation based on in vivo data available. Each topic contains a study report and database / handbook entries, which all consistently show that IPGE is moderately irritating to the skin / eye. There is no indication given that this result, commonly based on rabbit data, is not relevant for humans. Also, all results are consistent and derived i.a. from definitively reliable sources, hence, the database is of good quality. No data gaps were identified, and so no further testing is required.
Justification for classification or non-classification
All available data sources consistently reveal that IPGE is a moderate skin / eye irritant, providing a solid database. Although this classification is not mentioned in Regulation (EC) 1272/2008, the description of the effects match best the categories Irritating to skin (Category 2) and Irritating to eyes (Category 2); categories corrosive and not classified are not reasonable here.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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