Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 276-012-7 | CAS number: 71786-55-5
Endpoint summary
Administrative data
Description of key information
Not skin irritant
Not eye irritant
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The study conducted on the test substance underline no effect of irritation adn corrosion on skin and eye.
The irritaton was measured by patch test technique on the intact skin.For erythema the irritation score is 0 in all tested animals.
For edema the irritatione score is 0.3 for #animal1, 0 for #animal2 and 0.3 for #animal3.
The test substance was used undiluited. The eyes of three male rabbits were examined for pre-existing casual injury. 100 mg of the test substance was placed into the conjunctival sac of the right eyes of the animals. The eyelids were then gently held together for two seconds. the left eyes served as control. The eyes were inspected after 24, 48, 72 hours.
To supporting the test substance study a read across study was used. The observed skin irritation consisted of very slight erythema in animal 1, which had resolved whitin 24 hours after exposure. Animals 2 and 3 showed no skin irritation after 4 hours of application of the test substance.
There was no evidence of a corrosive effect on the skin.
Blue staining of the treated skin by the test substance was observed in each animal during the study period of 4 days.
No symptoms of systemic toxicity were observed in the animals during the test period and no mortality occurred.
Installation of the test substance affected the conjunctivae. The irritation of the conjunctivae had resolved within 14 days in all three animals.
There was no evidence of ocular corrosion.
No toxic symptoms were observed in the animals during the test period and no mortality occured.
Justification for classification or non-classification
The study conducted on the test substance underline no effect of irritation adn corrosion on skin and eye.
The irritaton was measured by patch test technique on the intact skin.For erythema the irritation score is 0 in all tested animals.
For edema the irritatione score is 0.3 for #animal1, 0 for #animal2 and 0.3 for #animal3.
The test substance is considered to be a non-irritant according to CLP (CE) n. 1272/2008 criteria.
The test substance was used undiluited. The eyes of three male rabbits were examined for pre-existing casual injury. 100 mg of the test substance was placed into the conjunctival sac of the right eyes of the animals. The eyelids were then gently held together for two seconds. the left eyes served as control. The eyes were inspected after 24, 48, 72 hours.
The test substance is considered to be a non-irritant to the skin according to CLP (CE) n. 1272/2008 criteria.
The observed skin irritation consisted of very slight erythema in animal 1, which had resolved whitin 24 hours after exposure. Animals 2 and 3 showed no skin irritation after 4 hours of application of the test substance.
There was no evidence of a corrosive effect on the skin.
Blue staining of the treated skin by the test substance was observed in each animal during the study period of 4 days.
No symptoms of systemic toxicity were observed in the animals during the test period and no mortality occurred.
According to CLP (CE) n. 1272/2008 criteria the test substance need not to be classified as skin irritant.
Installation of the test substance affected the conjunctivae. The irritation of the conjunctivae had resolved within 14 days in all three animals.
There was no evidence of ocular corrosion.
No toxic symptoms were observed in the animals during the test period and no mortality occured.
According to CLP (CE) n. 1272/2008 criteria, the test substance need not to be classified as eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
