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EC number: 239-717-0 | CAS number: 15647-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980-08
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Method: U.S. Consumer Product Safety Commission, Code of Federal Regulations, Title 16, Section 1500.41; Evaluation with Draize scores.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-aminomethyl-3,5,5-trimethylcyclohexan-1-ol
- EC Number:
- 239-717-0
- EC Name:
- 3-aminomethyl-3,5,5-trimethylcyclohexan-1-ol
- Cas Number:
- 15647-11-7
- Molecular formula:
- C10H21NO
- IUPAC Name:
- 3-(aminomethyl)-3,5,5-trimethylcyclohexan-1-ol
- Test material form:
- liquid: viscous
- Details on test material:
- 3-aminomethyl-3,5,5-trimethylcyclohexan-1-ol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Strain: New Zealand white
- Source: J. Scheele, Büderich/Westf., 4760 Werl
Housing conditions:
- Room temperature: 20°C (+/- 1°C);
- Light: 12 hours/day;
- Access to drinking water: ad libitum;
- Diet: K4 diet for rabbits (Ssniff; Soest)
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved, intact and scarified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- undiluted
Amound applied: 0.5 ml - Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- Postexposure period: 14 days
- Number of animals:
- 6
- Details on study design:
- ADMINISTRATION:
- Volume administered or concentration: 0.5 ml
- Post dose observation period: 48 hours
- Application to both intact and scarified skin
EXAMINATIONS: 24 and 72 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h and 72 h
- Score:
- 2.25
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- necrosis, strong incrustion
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h and 72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 h and 72 h
- Score:
- 3.6
- Max. score:
- 8
- Irritant / corrosive response data:
- AVERAGE SCORE
- Erythema: 2.25
- Edema: 1.33
24 hours after application all rabbits showed necrosis and slight to moderate oedem, 72 hours after application all rabbits showed strong incrustions - Other effects:
- no
Any other information on results incl. tables
no further remarks
Applicant's summary and conclusion
- Conclusions:
- Under the present conditions of this study necrosis, strong incrustions and slight to moderate oedema were observed after application of 0.5 ml itest tem (24 hrs exposure) to both intact and sacrified skin of rabbits. Therfore, test item is strong irritating to skin.
- Executive summary:
The acute skin irritation properties of the test item were estimated in a modified Draize test. A dose of 0.5 ml test item per animal was applied to both intact and sacrified skin of 6 rabbits under occlusive conditions. After a 24 -hours exposure period the patch was removed and skin irritation was assessed using Draize scale. The average scores at 24 and 72 hours after patch removal are as follows:
- Erythema: 2.25
- Edema: 1.33
24 hours after application all rabbits showed necrosis and slight to moderate oedem, 72 hours after application all rabbits showed strong incrustions.
Therfore, test item is strong irritating to skin.
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