Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 216-036-7 | CAS number: 1478-61-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
With an experimental log Kow value at 2.79 (Bär, 2017), the substance is not expected to bioaccumulate in aquatic organisms and does not meet the bioaccumulative (B) or very bioaccumulative (vB) screening criterion (log Kow < 4.5). This is confirmed with experimental fish BCF values between 5.2 and 9.8 L/kg (Shi et al., 2016), well below the cut-off values of 2000 L/kg. In addition, at the end of a 24 h depuration phase, 80 % of whole fish BPAFconcentrations had dissipated demonstrating that the substance was rapidly eliminated from the fish. The results conclude that the registered substance, BPAF, is not considered bioaccumulative in aquatic organisms.
Equivalent to log Kow for bioaccumulation in aquatic organisms, log Koa (octanol-air partition coefficient) has been recognised as a parameter indicating that bioaccumulation can occur in air-breathing (terrestrial) organisms. Available information on log Koa and log Kow as provided in the Integrated Testing Strategy for B-assessment of the ECHA Guidance Chapter R.11 (June 2017) may indicate if the substance is potentially bioaccumulative in air-breathing organisms (log Kow > 2 AND log Koa > 5). Based on the log Kow at 2.79 and an estimated Henry's Law Constant of 4.2E-06 Pa.m³/mol at 12°C (calculated with the vapour pressure value: 5E-06 Pa at 20°C; water solubility value: 222.4 mg/L at 20°C; and molecular weight of the substance: 336.229 g/mol), the registered substance has an estimated log Koa at 11.54, indicating potential to bioaccumulate in air-breathing organisms. However, the toxicokinetics (TK) of BPAF studied by Li et al., (2013, seen in IUCLID Section 7) showed that it was “eliminated completely at 48 hrs” following oral dosing in rats, and was metabolized quickly. Recent toxicokinetics studies in rats and mice (Waidyanatha et al, 2019, NTP) found plasma elimination half-lives of less than 4.22 h in rats and mice and extensive conjugation leading to low bioavailability. These data indicate that the registered substance is not likely to bioaccumulate in mammals.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.