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EC number: 240-642-0 | CAS number: 16587-71-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: a study similar to OECDTG401: LD50 = 4700 mg/kg bw
Acute inhalation toxicity LC50 route to route extrapolation = 12200 mg/m3
Acute dermal toxicity: a study similar to OECDTG402: LD50 = 4700 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Study was performed predating current guidelines
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 3.2, 4.0, 5.0 and 6.3 g/kg bw
- No. of animals per sex per dose:
- 10 animals (sex unspecified) per dose group
- Control animals:
- no
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 700 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 4 020 - <= 5 500
- Mortality:
- 3/10, 6/10 and 9/10 animals died in the 7 day observation period after exposure to 4.0, 5.0 and 6.3 g/kg respectively
Distribution of mortality:
- 3200 mg/kg dose group: no mortality occurred
- 4000 mg/kg bw dose group: 1 animal died on day 1 and 2 animals died on day 3.
- 5000 mg/kg bw dose group: 1 animal died on day 1 and day 2, 3 animals died on day 5.
- 6300 mg/kg bw dose group: 6 animals died on day 1, 2 animals died on day 2 and 1 animal died on day 5. - Clinical signs:
- Immediate stimulation followed by ataxia (uncoordinated movements)
- Gross pathology:
- Enteritis (inflammation of the gut) was seen.
- Interpretation of results:
- other: Not acute harmful
- Remarks:
- in accordance with CLP (1272/2008 and its updates)
- Conclusions:
- The acute oral toxicity test showed an LD50 of 4700 mg/kg bw
- Executive summary:
A pre-guideline study, equivalent to OECD guideline 401, was performed to identify the acute oral toxicity of the test substance. In this study 10 rats (sex unspecified) were administered with 3.2, 4.0, 5.0 and 6.3 g/kg bw. 3/10, 6/10 and 9/10 animals died in the 7 day observation period after exposure to 4.0, 5.0 and 6.3 g/kg respectively. Directly after dosing stimulation and ataxia (uncoordinated movements) were seen. Enteritis (inflammation of the gut) was seen at gross pathology. Under the conditions of the test, the acute oral LD50 for the test substance in rat was determined to be 4700 mg/kg bw. Based on these results, the test substance is not considered to be acute harmful.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Study was performed predating current guidelines
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- Not specified
- Doses:
- 3.2, 4.0, 5.0 and 6.3 g/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 700 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 4 200 - <= 5 260
- Mortality:
- 1/6, 5/6 and 6/6 animals died in the 7 day observation period after exposure to 4.0, 5.0 and 6.3 g/kg respectively
Distribution of mortality:
- 3200 mg/kg bw: no mortality
- 4000 mg/kg bw dose group: 1 animal died on day 5
- 5000 mg/kg bw dose group: 3 animals died on day 2 and 2 animals died on day 4.
- 6300 mg/kg bw dose group: 6 animals died on day 1 - Clinical signs:
- Ataxia (uncoordinated movements) and dermal irritation was seen.
- Gross pathology:
- Hemorrhagic enteritis (inflammation of the gut) was seen.
- Interpretation of results:
- other: Not acute harmful
- Remarks:
- in accordance with CLP (1272/2008 and its updates)
- Conclusions:
- The acute dermal toxicity test showed an LD50 of 4700 mg/kg bw in rabbits.
- Executive summary:
A pre-guideline study, equivalent to OECD guideline 402, was performed to identify the acute dermal toxicity of the test substance. In this study 6 rabbits (sex unspecified) were administered 3.2, 4.0, 5.0 and 6.3 g/kg bw test substance on the skin. 1/6, 5/6 and 6/6 animals died in the 7 day observation period after exposure to 4.0, 5.0 and 6.3 g/kg respectively. Clinical signs was ataxia and hemorrhagic enteritis during gross pathology. Under the conditions of the test, the acute dermal LD50 for the substance in rabbits was 4700 mg/ kg bw. Based on these results, the test substance is not considered to be acute harmful.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Acute oral toxicity
A pre-guideline study, equivalent to OECD guideline 401, was performed to identify the acute oral toxicity of the test substance. In this study 10 rats (sex unspecified) were administered with 3.2, 4.0, 5.0 and 6.3 g/kg bw. 3/10, 6/10 and 9/10 animals died in the 7 day observation period after exposure to 4.0, 5.0 and 6.3 g/kg respectively. Directly after dosing stimulation and ataxia (uncoordinated movements) were seen. Enteritis (inflammation of the gut) was seen at gross pathology. Under the conditions of the test, the acute oral LD50 for the test substance in rat was determined to be 4700 mg/kg bw. Based on these results, the test substance is not considered to be acute harmful.
Acute inhalation toxicity
The acute inhalation toxicity for the substance can be derived using data on the acute oral toxicity using the following methodology: CLP guidance (2017; 3.1.5.1.8. Example 8, page 264): using the extrapolation formula 1 mg/kg bw = 0.0052 mg/L/4h. The LD50 of the substance for acute oral toxicity is 4700 mg/kg bw. This value can be converted to 24.44 mg/L or 24.44 g/m3. Taking into account the inhalation absorption as 100% and oral absorption 50%, the acute inhalation toxicity would become 12.22 g/m3 = 12220 mg/m3. The maximum saturated vapour concentration for the substance is 287 mg/m3 (4.2 Pa (vapour pressure) x 168.28 (MW)) / (8.3 (R, gas constant) x 297 (°K)). This means that the substance cannot reach a concentration higher than 287 mg /m3. The extrapolated inhalation LC50 cannot be reached because it exceeds the saturated vapour pressure by more than a factor of 42.
Acute dermal toxicity
A pre-guideline study, equivalent to OECD guideline 402, was performed to identify the acute dermal toxicity of the test substance. In this study 6 rabbits (sex unspecified) were administered 3.2, 4.0, 5.0 and 6.3 g/kg bw test substance on the skin. 1/6, 5/6 and 6/6 animals died in the 7 day observation period after exposure to 4.0, 5.0 and 6.3 g/kg respectively. Clinical signs was ataxia and hemorrhagic enteritis during gross pathology. Under the conditions of the test, the acute dermal LD50 for the substance in rabbits was 4700 mg/ kg bw. Based on these results, the test substance is not considered to be acute harmful.
Justification for classification or non-classification
Based on the available information classification and labelling for acute oral, dermal and inhalation toxicity is not warranted in accordance with EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008 and its amendments.
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