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Diss Factsheets
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EC number: 203-430-9 | CAS number: 106-75-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1968
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Unsuitable test system. Inadequate route of exposure. Documentation insufficient for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Estimation of the acute LD50 following single i.p. injection.
- GLP compliance:
- no
Test material
- Reference substance name:
- Oxydiethylene bis(chloroformate)
- EC Number:
- 203-430-9
- EC Name:
- Oxydiethylene bis(chloroformate)
- Cas Number:
- 106-75-2
- Molecular formula:
- C6H8Cl2O5
- IUPAC Name:
- oxydiethane-2,1-diyl dichlorocarbonate
- Details on test material:
- Degree of purity not reported.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kisslegg
- Weight at study initiation:
ENVIRONMENTAL CONDITIONS
no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: water with Traganth
- Doses:
- 25, 32, 50, 64, 100, 160, 200, 1600 µl/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing was prior to the application for dose calculation. Observations were several time at the day of administration and once daily after wards except on weekends.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- none
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 56 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 0.04 mL/kg bw
- Mortality:
- Mortality: LD50 was about 40 µl/kg bw, equivalent to 56 mg/kg bw, based on a density of 1.39 g/ml.
25 µl/kg: 0/10
32 µl/kg: 1/10
50 µl/kg and 64 µl/kg: 8/10
100 µl/kg, 160 µl/kg, 200 µl/kg and 1600 µl/kg: 10/10 - Clinical signs:
- Dyspnea, tremor.
- Body weight:
- not determined
- Gross pathology:
- Adhesions in the abdominal cavity.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.