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EC number: 247-092-0 | CAS number: 25549-16-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Triisooctylamine
- EC Number:
- 247-092-0
- EC Name:
- Triisooctylamine
- Cas Number:
- 25549-16-0
- Molecular formula:
- C24H51N
- IUPAC Name:
- tris(6-methylheptyl)amine
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Lot/batch No.: 0008924462
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, Germany
- Age at study initiation: male animals approx. 8 weeks, female animals approx. 12 weeks
- Weight at study initiation: animals of comparable size and weight
- Fasting period before study: N/A
- Housing: Single housing
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 22 °C +- 3 °C
- Humidity: 30 – 70 %
- Air changes (per hr): ca. 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal and dorsolateral parts of the trunk)
- % coverage: About 40 cm² (corresponds to at least 10% of the body surface)
- Type of wrap if used: The test item was covered with an air-permeable dressing (4 layers of absorbent gauze (Ph. Eur. supplied by Lohmann GmbH & Co., KG) and stretch bandage (Fixomull® Stretch (adhesive fleece) supplied by Beiersdorf AG).
REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsing of the application site with warm water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.47 mL/kg
- Constant volume or concentration used: yes - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical signs for each animal were recorded several times on the day of application and at least once during each workday thereafter. Individual body weights shortly before application (day 0), weekly thereafter and on the last day of observation. Individual readings 30 – 60 minutes after removal of the semi-occlusive dressing (day 1), several times (see results) until the last day of observation. A check for any dead or moribund animals was made at least once each workday.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, necropsy with gross-pathology examination was performed on the last day of the observation period after sacrifice by CO2-inhalation in a chamber with gradually increasing concentrations. - Statistics:
- N/A
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality occurred
- Mortality:
- No mortality occurred
- Clinical signs:
- other: No systemic clinical signs were observed during clinical examination. Local effects see below.
- Gross pathology:
- No macroscopic pathologic abnormalities were noted in the animals (5 males and 5 females) examined on the last day of observation.
Any other information on results incl. tables
Local effects males:
In all animals of the male group well-defined erythema (grade 2) was observed on study day 1 and persisted in four of these animals until study day 2, while in one animal severe erythema (grade 4) was noticed on the same day. On study day 3, one male showed moderate erythema (grade 3), while in the other animals severe erythema (grade 4) was noted. Severe erythema (grade 4) was noted persisted in three animals until study day 8, and in one male each until day 10 or day 13. Thereafter, moderate erythema (grade 3) was observed in two males from study day 9 until study day 10 or day 14. In another animal this grade was observed from study day 13 until study day 14, while in a further male animal grade 3 was observed only on study day 14. The fifth animal revealed well-defined erythema (grade 2) from study day 9 until study day 14.
Slight edema (grade 2) was noted in all male animals on study day 1 and persisted in four animals until study day 2. In one animal moderate edema (grade 3) was observed from study day 2 until day 3 and in the other four animals on study day 3. On study day 6, all animals showed severe edema (grade 4) which persisted in one animal up to study day 7. In this animal the finding decreased to moderate edema (grade 3) on day 8. In the other animals moderate edema (grade 3) was observed on study day 7 and persisted in one animal until day 8 and in two other animals until study day 10. Slight edema (grade 2) was seen in two male animals from study day 8 or 9 until study day 10 and in a third animal from day 9 until day 14. The two other animals revealed slight edema from study day 13 up to study day 14. In two animals edema decreased to very slight edema (grade 1) and was seen from study day 13 until study day 14. Dermal blisters were noted in 4 male animals on study day 1. From study day 2 until study day 14, incrustations were noted in all animals. In addition, scaling was seen in all males from study day 6 until study day 10 and persisted in one male until day 14.. Erythema and edema beyond the application area were noted in three animals from study day 6 until study day 10 or 13. Descriptions of any dermal finding were recorded in the table of results as raw data.
Local effects females:
In all animals of the female group well-defined erythema (grade 2) was noted from study day 1 until study day 2 and persisted in two of these animals up to study day 3, while in the other three females moderate erythema (grade 3) was noted on the same day. Thereafter, severe erythema (grade 4) was observed in all animals until study day 10 and persisted in four females up to study day 14, while in the fifth female moderate erythema (grade 3) was seen from study day 13 until study day 14. In all females slight edema (grade 2) was observed from study day 1 until study day 2 and persisted in four females up to study day 3, while in one animal moderate edema (grade 3) was observed on study day 3. On study day 6, severe edema (grade 4) was seen in all female animals and persisted in four of these females up to study day 7. In one female moderate edema (grade 3) was seen on study day 7, which decreased to slight edema (grade 2) from study day 8 until day 14. Moderate edema (grade 3) was noticed in four females on study day 8 and persisted in two of these females up to study day 10. Slight edema (grade 2) was noticed in two of these females on study day 9 and persisted in these animals up to study day 10 or 14.
In three females very slight edema (grade 1) was noted from study day 13 until study day 14. Dermal blisters with partly destroyed uppermost layer of the skin were noted in one female animal on study day 1. Eczema like skin lesion was seen in two females from study day 9 until day 14. From study day 2 or 3 until study day 14 incrustations were noted in all animals. In addition, scaling was seen from study day 6 until study day 14 in these animals. Erythema and edema beyond the application area were noted from study day 6 until study day 13 or 14 in three animals. In the two remaining animals findings beyond the application area were noted on study day 13 only. Descriptions of any dermal finding were recorded in the table of results as raw data.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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