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Diss Factsheets
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EC number: 235-546-0 | CAS number: 12270-13-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Federal Hazardous Substances Labelling Act (Section 191.12)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-[[4-[ethyl(2-hydroxyethyl)amino]phenyl]azo]-6-methoxy-3-methylbenzothiazolium chloride
- EC Number:
- 248-053-0
- EC Name:
- 2-[[4-[ethyl(2-hydroxyethyl)amino]phenyl]azo]-6-methoxy-3-methylbenzothiazolium chloride
- Cas Number:
- 26850-47-5
- Molecular formula:
- C19H23ClN4O2S
- IUPAC Name:
- 2-[(E)-{4-[Ethyl(2-hydroxyethyl)amino]phenyl}diazenyl]-6-methoxy-3-methyl-1,3-benzothiazol-3-ium chloride
- Test material form:
- solid
- Details on test material:
- see below
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Details on test animals or tissues and environmental conditions:
- not specified
Test system
- Details on study design:
- Tests for eye irritation in albino rabbits were conducted as outlined in the Federal Hazardous Substances Labelling Act (Section 191.12 of the Regulations).
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks on result:
- other:
- Remarks:
- see box "irritant / corrosive response data"
- Irritant / corrosive response data:
- One hour - The conjunctiva of all rabbits showed a mild degree of inflammation (hyperaemia, grade 1); Chemosis was recorded as grade 1, and there was a discharge (lacrimation). In addition, the conjunctiva was coloured blue. In 24 and 36 hours, the local changes were essentially the same. After 48 hours, the bluish colour of the conjunctiva was less conspicuous. After 72 hours, the local changes (hyperaemia, Chemosis) had almost completely disappeared, but lacrimation continued in two of the six rabbits for approximately 10 days. One rabbit showed a 1 mm area of injury of the conjunctiva from 24 to 72 hours after treatment, as identified by the fluorescein test (possibly due to rubbing the eye against the cage).
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- In an in vivo eye irritation study the test item was applied to the eye of rabbits as outlined in the Federal Substances Labelling Act (Section 191.12 of the Regulations). By comparison of the eye changes reproduced in the "Guides" prepared by the Dermal Toxicity Branch of the Bureau of Scientific Standards and Evaluation, Food and Drug Administration, the material is not an eye irritant.
- Executive summary:
In an in vivo eye irritation study the test item was applied to the eye of rabbits as outlined in the Federal Substances Labelling Act (Section 191.12 of the Regulations). By comparison of the eye changes reproduced in the "Guides" prepared by the Dermal Toxicity Branch of the Bureau of Scientific Standards and Evaluation, Food and Drug Administration, the material is not an eye irritant. Due to a poor documentation of the results this report was assigned with a Klimisch score of 4.
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