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Diss Factsheets
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EC number: 201-615-9 | CAS number: 85-56-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 07, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Remarks:
- and microscopic examination
- Type of particle tested:
- primary particle
- Type of distribution:
- volumetric distribution
- Mass median aerodynamic diameter:
- 17.388 µm
- Key result
- Percentile:
- D50
- Mean:
- 16.096 µm
- St. dev.:
- 3
- Remarks on result:
- other: 3%
- No.:
- #5
- Size:
- 4.446 µm
- Distribution:
- 10 %
- No.:
- #5
- Size:
- 16.096 µm
- Distribution:
- 50 %
- No.:
- #5
- Size:
- 46.425 µm
- Distribution:
- 90 %
- No.:
- #5
- Size:
- 10 µm
- Distribution:
- 29.95 %
- Remarks on result:
- other:
- Remarks:
- by volume of sample
- Conclusions:
- Under the study conditions, the following particle size distribution measures were found to be: MMAD (Mass Median Aerodynamic Diameter) 17.388 μm; 10 % of material is < 4.446 μm; 50 % of material is < 16.096 μm; 90 % of material is < 46.425 μm; 29.95 % by volume of sample was seen to be < 10.00 μm.
- Executive summary:
A study was conducted to determine particle size distributions of the test substance using microscopic observations and laser diffraction particle size analysis according to ISO 13320:2009 and CIPAC MT 187 taking into consideration OECD 110 Guideline, in compliance with GLP. The sample was initially observed to determine whether sieving of the material is required prior to analysis. Subsequently the method development was employed to identify the most appropriate optical properties for the material, the correct dispersant, dispersion pressures and sample compatibility. Once these parameters were obtained the final sample was analysed over the range 0.02 μm to 2000 μm using the Malvern Mastersizer 2000 Laser Diffraction Analyser. 5 runs were completed to ensure repeatability of results. Under the study conditions, the following particle size distribution measures were found to be: MMAD (Mass Median Aerodynamic Diameter) 17.388 μm; 10 % of material is < 4.446 μm; 50 % of material is < 16.096 μm; 90 % of material is < 46.425 μm; 29.95 % by volume of sample was seen to be < 10.00 μm (Younis, 2016).
Reference
Microscopic observations
Standard visual observation: sample observed to be a medium to fine white powder with lumps and clusters.
Observation at 100 x magnification: the particles appeared to be irregular shaped crystals. The smallest individual particle size was
approximately 3 μm and the largest individual size was approximately 80 μm.
Observation at 400 x magnification: the sample was observed to be made up of single crystalline particles with some agglomerations.
Laser diffraction particle size analysis
29.95 % by volume of sample was seen to be < 10.00 μm.
Coefficient of variation for d50 is less than 3 %; d10 and d90 are less than 5 %.
Description of key information
Determination of the particle size distribution according to ISO 13320:2009 and CIPAC MT 187 taking into consideration OECD Guideline 110 (Younis, 2016).
Additional information
MMAD (Mass Median Aerodynamic Diameter) 17.388 μm; 10 % of material is < 4.446 μm; 50 % of material is < 16.096 μm; 90 % of material is < 46.425 μm; 29.95 % by volume of sample was seen to be < 10.00 μm.
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