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Diss Factsheets
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EC number: 202-675-9 | CAS number: 98-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The distribution of 14Cp-ter.-butyltoluene (TBT) following inhalation by the rat: A whole body autoradiographic study.
- Author:
- Ingebrigtsen K and Walde A
- Year:
- 1 982
- Bibliographic source:
- Acta pharmacol et toxicol 51: 203-208.
- Reference Type:
- publication
- Title:
- Metabolism of p-tert.-Butyltoluene in the Rat and Guinea Pig.
- Author:
- Walde A and Scheline RR
- Year:
- 1 983
- Bibliographic source:
- Acta Pharmacol Toxicol 53: 57-63.
Materials and methods
- Objective of study:
- excretion
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-tert-butyltoluene
- EC Number:
- 202-675-9
- EC Name:
- 4-tert-butyltoluene
- Cas Number:
- 98-51-1
- Molecular formula:
- C11H16
- IUPAC Name:
- 1-tert-butyl-4-methylbenzene
- Details on test material:
- (methyl-14C)p-tert-butyltoluene; according to the authors, radiochemical purity was 98-99%; no further data
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C
Test animals
- Species:
- other: rat, guinea pig
- Strain:
- other: Wistar (rat), Dunin Hartley (guinea pig)
- Sex:
- male
Administration / exposure
- Route of administration:
- other: intragastric, inhalation
- Vehicle:
- not specified
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg/kg bw
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parametersopen allclose all
- Toxicokinetic parameters:
- half-life 2nd:
- Toxicokinetic parameters:
- half-life 1st:
- Toxicokinetic parameters:
- half-life 3rd:
Any other information on results incl. tables
The elimination of the test substance after intragastric and inhalational administration (doses of 100 mg/kg) was studied in male Wistar rats and in male Dunkin Hartley guinea pigs.
The test substance was well absorbed through the gastro-intestinal and respiratory tract, was quickly distributed, and was eliminated within a few days.
In rats, 73% of a single oral dose (100 mg/kg) was recovered in the urine and feces within 3 days. After 10 days, 83% of the administered dose was recovered; the ratio of urinary/fecal radioactivity was ca. 3.5 : 1. Elimination was biphasic with the slower elimination phase beginning on day 6 after dosing.
At day 3 after dosing, urinary excretion of radioactivity was 45% and 25% after oral and inhalational exposure, respectively, in rats and 42% and 41% after oral and inhalational administration, respectively, in guinea pigs.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.