Registration Dossier
Registration Dossier
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EC number: 221-897-7 | CAS number: 3271-76-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977/78
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Register 38 No 187 § 1500.41, S. 27019 dated 27.09.73. Evaluation accordig to Draize, J.H. (1959): Dermal Toxicity. In: FDA-Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics
- GLP compliance:
- no
Test material
- Reference substance name:
- Anthra[2,1,9-mna]naphth[2,3-h]acridine-5,10,15(16H)-trione
- EC Number:
- 221-897-7
- EC Name:
- Anthra[2,1,9-mna]naphth[2,3-h]acridine-5,10,15(16H)-trione
- Cas Number:
- 3271-76-9
- Molecular formula:
- C31H15NO3
- IUPAC Name:
- anthra[2,1,9-mna]naphth[2,3-h]acridine-5,10,15(16H)-trione
- Test material form:
- liquid
- Details on test material:
- Vat Green 3
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: on part shaved, on part shaved and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 24, 72 hours, 8 days
- Number of animals:
- 6
- Details on study design:
- SCORING SYSTEM:
Erythema and Edema
1 - questionable, very mild
2 - mild
3 - severe
4 - most intensive
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- at 24 h, and in some animals at 72 h, erythema evaluation was not possible due to staining of the skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No indication of skin irritation was seen in intact and scarified rabit skin.
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