Reaction mass of Amines, C10-14-branched and linear alkyl, bis[2,4-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)] chromate(1-) (1:1) and Amines,C10-14-branched and linear alkyl, bis[2,4-dihydro-4-[(2-hydroxy-4-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)] chromate(1-)

Endpoint summary

Description of key information

Acute oral toxicity study (equivalent to OECD 401) with the constituent CAS 85029-57-8: LD50 > 10000 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Please refer to the attached document for the read-across justification.

Reason / purpose for cross-reference:

read-across source

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 10 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Based on read-across from CAS 85029-57-8

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

discriminating dose

Value:

10 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

No acute oral toxicity data is availalble on the substance itself. Therefore read-across is performed to the main constituent with CAS 85029-57-8. No correction for the composition was applied on the effect level, since the major component was used for the assessment.

CAS No. 85029-57-8

In a study equivalent to OECD Guideline 401, the acute toxicity of CAS No. 85029-57-8 was tested using male and female Gassner rats. 5 animals/sex/dose were exposed to a single dose of 8000 and 10000 mg/ kg bw test substance. Carboxymethyl cellulose (CMC) was used as vehicle and the substance was administered as a watery 30% suspension. Animals were observed during a period of 14 days after 1 hour, 24 hours, 48 hours, 7 days and 14 days and necropsy of survivors was performed. No mortality was observed. Fast breathing during the first 3 hours after application. Necropsy revealed mild red staining of organs in both dose groups and 3 or 2 animals (in the 8000 and 1000 mg/kg bw dose group, respectively) had a parasite infection of the caecum (oxyuren). Based on these data the LD50 was determined to be above 10000 mg/kg bw (BASF 1972). 

Justification for classification or non-classification

Based on the results of the available information, classification of the substance for acute oral toxicity is not warranted in accordance with EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation No. (EC) 1272/2008.