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Diss Factsheets
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EC number: 947-119-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Treatment with di C8-C10, branched, C9 rich, alkylnaphthalene sulphonic acid (DNNSA) by oral gavage in male and female Wistar Han rats in a combined 28-day repeated dose toxicity study with the reproduction/developmental toxicity screening at dose levels of 95, 298, and 893 mg/kg body weight/day revealed parental toxicity at 298 and 893 mg/kg body weight/day. No reproduction toxicity was observed for treatment up to 893 mg/kg body weight/day.
Parental NOAEL: 95 mg/kg/day
Reproduction NOAEL: at least 893 mg/kg/day
Developmental NOAEL: 893 mg/kg/day
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 893 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- guideline study under GLP
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
In a 90 -day study with the calcium salt of the substance no effects on the gonads were found. This is an additional indication that no effects on fertility are expected.
Effects on developmental toxicity
Description of key information
A Combined 28-day repeated dose toxicity study with the reproduction/developmental toxicity screening test ofdi C8-C10, branched, C9 rich, alkylnaphthalene sulphonic acid(DNNSA) was conducted in rats by oral gavage (OECD 422). Developmental toxicity in the form of lower pup body weight in female pups was observed at the high dose of 893 mg/kg on day 4 after birth. There were no significant differences on day 1 in female pups, in male pups on day 1 or day 4 or in combined male and female pup weights on either day 1 or day 4 after birth. No developmental toxicity was observed for the lower treatment groups of 95 and 298 mg/kg body weight/day. Based on the lower female pup weight difference at day 4, the NOAEL was very conservatively set at 298 mg/kg body weight/day. However, clear parental effects were seen at 893 mg/kg bw/d. This included mortality of 4 males and one female and, moreover, some of the clinical signs seen in sacrificed animals were observed in surviving animals. Taken together, the evidence for developmental effects at 893 mg/kg/day is weak or equivocal and very likely secondary to maternal toxicity. As a consequence, for risk assessment purposes the high dose treatment of 893 mg/kg/day is considered the appropriate NOAEL.
Parental NOAEL: 95 mg/kg/day
Reproduction NOAEL: at least 893 mg/kg/day
Developmental NOAEL: 893 mg/kg/day
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 893 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Guideline study under GLP
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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