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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 944-188-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-standard animal species; non-GLP
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Long-term clearance of inhaled magnetite and polystyrene latex from the lung: a comparison
- Author:
- Schlesinger RB, Halpern M, Lippman M
- Year:
- 1 981
- Bibliographic source:
- Health Physics 42, 68-73
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- Commercial magnetite of an MMAD of ~3 µm was selected. Measurement indicated an MMAD of 3.4 µm. The purity was 98%. The material was neutron-activated to produce an activity of 125 µCi/g of 59Fe Number of animals: 4 Duration of Exposure: 4 h
Concentration: 30- 85- 151- 161 mg/m³ corresponding to lung burdens of 21- 64- 75- 110 mg Clearance
was measured radiometrically 1-2-4-7 days after exposure, then weekly for 12 weeks and bimonthly until ~210 days post
exposure. Activity at 24 h post dose was set as 100% (= no clearance from the alveoli) - GLP compliance:
- no
Test material
- Reference substance name:
- Triiron tetraoxide
- EC Number:
- 215-277-5
- EC Name:
- Triiron tetraoxide
- Cas Number:
- 1317-61-9
- Molecular formula:
- Fe3O4
- IUPAC Name:
- Triiron tetraoxide
- Details on test material:
- Test substance: magnetite (purity 98%)
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- other: donkey
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- 4 hour(s)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Males: 30, 85, 151, 161 mg/m³ Females: 30, 85, 151, 161 mg/m³
- No. of animals per sex per dose / concentration:
- Males: 2 Females: 2
- Control animals:
- no
Results and discussion
- Preliminary studies:
- no data
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- no data
- Details on distribution in tissues:
- no data
- Details on excretion:
- see toxicokinetik parameters
Toxicokinetic parametersopen allclose all
- Toxicokinetic parameters:
- half-life 2nd: 42 - 173 days
- Toxicokinetic parameters:
- half-life 1st: 15 - 22 days
Metabolite characterisation studies
- Metabolites identified:
- no
- Details on metabolites:
- inert particles - no metabolites identified (not examined)
Any other information on results incl. tables
Magnetite showed a two-phase lung clearance with halflives of about 3 weeks in the first phase and several months in the second phase
Applicant's summary and conclusion
- Executive summary:
Commercial magnetite of an MMAD of ~3 µm was selected . Measurement indicated an MMAD of 3.4 µm.
The purity was 98%. The material was neutron-activated to produce an activity of 125 µCi/g of 59Fe Number
of animals: 4 Duration of Exposure: 4 h Concentration: 30- 85- 151- 161 mg/m³ corresponding to lung burdens
of 21- 64- 75- 110 mg Clearance was measured radiometrically 1-2-4-7 days after exposure, then weekly for
exposure. Activity at 24 h post dose was set as 100% (= no clearance from the alveoli)
As a result Magnetite showed a two-phase lung clearance with halflives of about 3 weeks in the first phase and several months in the second phase
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