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Diss Factsheets
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EC number: 235-310-7 | CAS number: 12163-26-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A repeated dose toxicity study with magnesium diniobate is not available, thus the repeated dose toxicity will be addressed with existing data on the individual constituents magnesium and niobium.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Magnesium diniobate
Since a repeated dose toxicity study is not available specifically for magnesium diniobate, information on the individual constituents magnesium and niobium will be used for the hazard assessment and when applicable for the risk characterisation of magnesium diniobate.
Magnesium
Magnesium, as one of the essential elements, is known for its U-shaped dose- response relationship. The U-shape dose-response describes a biphasic response to exposure to increasing amounts of a substance or condition. According to a recently published EFSA scientific opinion on dietary reference values for magnesium the daily recommendation for magnesium is between 300 and 350 mg/day. Variation in intake recommendations depends on age, sex and health. However, redistribution, reduced intake, reduced intestinal absorption, increased gastrointestinal loss or increased renal loss are causes of hypomagnesaemia. Magnesium deficiency entirely due to reduced dietary intake in otherwise healthy subjects is very uncommon. This kind of deficiency is mainly observed in patients with diseases. Magnesium deficiency has severe effects on human health, due to its biological role, e.g. as essential cofactor in enzymatic processes. Excessive use of magnesium as laxatives, antacids or daily magnesium supplementation has only mild and reversible effects on human health. However, magnesium deficiency is more relevant to human health than magnesium overdoses.
Niobium
A combined repeated dose toxicity study with reproduction/developmental toxicity screening test according to OECD Guideline 422 in which diniobium pentaoxide was administered by gavage to Wistar rats at dose levels of 250, 500 and 1000 mg/kg bw/day is considered as the key study for repeated dose toxicity. After oral administration of 250, 500, and 1000 mg/kg bw/day of diniobium pentaoxide, adverse test item related effects were not observed for clinical signs, mortality, body weight, body weight changes, food consumption, haematology, clinical chemistry, neurobehavioural examinations, organ weights, gross pathology, and histopathology. In conclusion, the No Observed Adverse Effect Level (NOAEL) for the substance was concluded to be ≥ 1000 mg/kg bw/day for male and female rats.
Justification for classification or non-classification
Magnesium diniobate does not require a classification for STOT-RE since adverse effects are not expected up to the limit dose based on infornation available for its constituents.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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