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EC number: 211-055-7 | CAS number: 628-81-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In the study by Smyth et al., 1951 an oral LD50 of 1870 mg/kg bw was reported for rats after a single application of butyl ethyl ether. Two studies are available to assess the acute inhalation toxicity of butyl ethyl ether. In the study by Marsh & Leake, 1950 the LC50 was determined to be 153000 mg/m³ in mice. In the study Smyth et al., 1951 six rats were exposed for 4 hours to 1000 ppm of butyl ethyl ether. Animals then were observed for 14 days. No mortality occurred. Thus, the LC50 can be considered to be greater than 1000 ppm (equals 4170 mg/m³).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- no data
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 870 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In the study by Smyth et al., 1951 an oral LD50 of 1870 mg/kg bw was reported for rats after a single application of the test item.
- Executive summary:
In the study by Smyth et al., 1951 an oral LD50 of 1870 mg/kg bw was reported for rats after a single application of butyl ethyl ether. The animals were observed for 14 days.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 870 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The aim of the study was to determine the anesthetic activity of all the commonly available ethers of from two to ten total carbon numbers.
- GLP compliance:
- no
- Test type:
- other: laboratory specific test protocol
- Limit test:
- no
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source: the compound was purchased on the open market
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: The test item was purified and freshly distilled just prior to use - Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- White mice, weight 18 to 24 g were used for the experiments.
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Twenty liter, wide-mouth, Pyrex jars were flushed out with oxygen and stoppered. A measured quantity of anesthetic agent was introduced after volatilization had taken place, four mice were placed in the jar. The jar was rotated by hand once every thirty seconds for fifteen minutes. Using this conditions, the mice have approximately 2.5 L of atmosphere available per kilogram of body weight per minute.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 15 min
- Concentrations:
- not specified
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- Four mice were placed in the jar. The jar was rotated by hand every thirty seconds for fifteen minutes. Any mouse that was unable to right itself for thirty seconds after being rolled on its back was considered anesthetized, and any mouse that developed respiratory collapse and did not recover on exposure to air after the jars was opened was considered dead. No pre-anesthetic medication was used and no attempt was made at reusecitation after removing the mice from the jar. The experiments were repeated until the quantity of ether was found that anesthetize 9 to 11 animals out of a total 20 (AC50), anesthetize 19 of 20 (AC95, 99), kill one (LC1-5), and kill 9 to 11 out of 20 (LC50).
- Statistics:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 153 000 mg/m³ air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 15 min
- Mortality:
- not specified, but to determine the LC50 9 to 11 out of 20 mice died
- Clinical signs:
- other: not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study, the test item was applied via the inhalation route to four mice for 15 minutes. The LC50 was determined to be 153000 mg/m³.
- Executive summary:
In an acute inhalation toxicity study, four white mice were exposed by inhalation route to butyl ethyl ether for 15 min. Any mouse that was unable to right itself for thirty seconds after being rolled on its back was considered anesthetized, and any mouse that developed respiratory collapse and did not recover on exposure to air after the jars was opened was considered dead. The experiments were repeated until the quantity of ether was found that anesthetize 9 to 11 animals out of a total 20 (AC50), anesthetize 19 of 20 (AC95, 99), kill one (LC1-5), and kill 9 to 11 out of 20 (LC50). As reported in the publication, the LC50 was determined to be 153000 mg/m³.
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study was conducted before OECD testing guidelines were established. 6 animals were treated via inhalation to a vapour of butyl ethyl ether for a total of 4 hours. Afterwards, the animals were observed for 14 days for mortality.
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- 1000 ppm (= 4170 mg/m³)
- No. of animals per sex per dose:
- 6 animals in total used, sex not specified
- Statistics:
- no data
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- 1 000 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 1 000 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- no mortality occurred
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute inhalation toxicity study 6 rats were exposed for 4 hours to 1000 ppm of butyl ethyl ether. Animals then were observed for 14 days. No mortality occured. Thus, the LC50 can be considered to be greater than 1000 ppm (equals 4170 mg/m³)
- Executive summary:
In an acute inhalation toxicity study 6 rats were exposed for 4 hours to 1000 ppm of butyl ethyl ether. Animals then were observed for 14 days. No mortality occured. Thus, the LC50 can be considered to be greater than 1000 ppm (equals 4170 mg/m³)
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the study by Smyth et al., 1951 an oral LD50 of 1870 mg/kg bw was reported for rats after a single application of butyl ethyl ether. Two studies are available to assess the acute inhalation toxicity of butyl ethyl ether. In the study by Marsh & Leake, 1950 the LC50 was determined to be 153000 mg/m³ in mice. In the study Smyth et al., 1951 six rats were exposed for 4 hours to 1000 ppm of butyl ethyl ether. Animals then were observed for 14 days. No mortality occurred. Thus, the LC50 can be considered to be greater than 1000 ppm (1000 ppm equals 4170 mg/m³).
Justification for classification or non-classification
Based on the results from an acute oral toxicity study, butyl ethyl ether does warrant classification for acute oral toxicity [Cat. 4, H302]. By assessing the available data for acute inhalation toxicity in rats and mice in a weight-of-evidence approach, no classification is warranted for acute inhalation toxicity.
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