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EC number: 216-784-4 | CAS number: 1667-10-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 April 2016 to 21 April 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of particle tested:
- agglomerate
- Type of distribution:
- volumetric distribution
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source: Provided by sposor
- Lot/batch No.of test material: 150701
- Expiration date of the lot/batch: 14 July 2017
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: - Storage conditions: Controlled room temperature (15-25 ºC, below 70 RH%), protected from humidity, under inert gas. - Mass median aerodynamic diameter:
- >= 554.13 - <= 565.76 µm
- Geometric standard deviation:
- >= 1.774 - <= 1.829
- Key result
- Percentile:
- D10
- Mean:
- 207.626 µm
- St. dev.:
- 8.052
- Remarks on result:
- other: Standard deviation of the population reported.
- Key result
- Percentile:
- D50
- Mean:
- 508.937 µm
- St. dev.:
- 3.952
- Remarks on result:
- other: Standard deviation of the population reported.
- Key result
- Percentile:
- D90
- Mean:
- 883.739 µm
- St. dev.:
- 4.953
- Remarks on result:
- other: Standard deviation of the population reported.
- No.:
- #1
- Size:
- < 10 µm
- Distribution:
- 0.31 %
- Conclusions:
- Under the conditions of this study the average size of the particles was determined to be 508.937 microns.
- Executive summary:
A determination of the particle size distribution of the test material was carried out in accordance to the standardised guidelines ISO 13320:2009, CIPAC MT 187 with consideration of OECD 110 under GLP conditions.
The particle size of the test material was determined through laser diffraction using a particle size analyser. The sample proved to be insoluble, and well dispersed in methanol, therefore methanol was used for the suspension fluid. 5 runs were perfomed to ensure repeatability of results.
Under the conditions of this study the average size of the particles was determined to be 508.937 microns.
Reference
Table 1. Full particle size test results
|
RUN 1 |
RUN 2 |
RUN 3 |
RUN 4 |
RUN 5 |
**Average |
Volume weighted Mean |
530.577 |
520.860 |
531.571 |
531.170 |
531.494 |
529.134 |
Median (d.50) |
510.431 |
501.070 |
510.875 |
510.729 |
511.582 |
508.937 |
Mode (μm) |
558.958 |
551.977 |
558.803 |
556.656 |
558.373 |
556.945 |
*MMAD |
564.48 |
554.13 |
564.97 |
564.81 |
565.76 |
562.83 |
10 % of material is < |
206.779 |
192.853 |
208.828 |
214.744 |
214.762 |
207.626 |
50 % of material is < |
510.431 |
501.070 |
510.875 |
510.729 |
511.582 |
508.937 |
90 % of material is < |
887.636 |
874.262 |
887.872 |
883.959 |
884.510 |
883.739 |
All results are in μm
* Mass Median Aerodynamic Diameter
** Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.
0.31 % by volume of sample was seen to be < 10.00 μm.
Standard Deviation Results
Run No. |
1 |
2 |
3 |
4 |
5 |
STDVP |
% STDVP |
D10 |
206.779 |
192.853 |
208.828 |
214.744 |
214.762 |
8.025 |
3.9 |
D50 |
510.431 |
501.070 |
510.875 |
510.729 |
511.582 |
3.952 |
0.8 |
D90 |
887.636 |
874.262 |
887.872 |
883.959 |
884.510 |
4.953 |
0.6 |
D15.78 |
283.475 |
273.962 |
284.755 |
287.852 |
287.869 |
5.110 |
1.8 |
GSD |
1.801 |
1.829 |
1.794 |
1.774 |
1.777 |
0.020 |
1.1 |
MMAD |
564.48 |
554.13 |
564.97 |
564.81 |
565.76 |
4.37 |
0.8 |
GSD = Geometric standard deviation of the lognormal particle size distribution
STDVP = standard deviation of the population
% STDVP = percentage standard deviation of the population
Coefficient of variation for d50 is less than 3 %; d10 and d90 are less than 5 %. Thus repeatability of the characteristic particles in the size distribution are within the acceptable limits as per the ISO 13320-1 test standard.
Description of key information
Under the conditions of this study the average size of the particles was determined to be 508.937 microns.
Additional information
A determination of the particle size distribution of the test material was carried out in accordance to the standardised guidelines ISO 13320:2009, CIPAC MT 187 with consideration of OECD 110 under GLP conditions. The study was assigned a reliability score of 1 in accordance with the criteria for assessing data quality set forth by Klimisch et al. (1997).
The particle size of the test material was determined through laser diffraction using a particle size analyser. The sample proved to be insoluble, and well dispersed in methanol, therefore methanol was used for the suspension fluid. 5 runs were perfomed to ensure repeatability of results.
Under the conditions of this study the average size of the particles was determined to be 508.937 microns.
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