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EC number: 947-057-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LLNA on analogue substance : not sensitising (OECD 429, GLP, K, rel.2)
GPMT : not sensitising (sim. OECD 406, rel.3)
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A key study was identified (RCC, 2007, rel.2). This Local Lymph Node Assay was conducted according to the OECD test guideline No 429 and in compliance with GLP on an analogue substance.
Five groups each of four female mice were treated daily with the test substance at concentrations of 2.5 %, 5 %, 10 %, 25 % and 50 %(w/v) in propylene glycol by topical application to the dorsum of each ear lobe (left and right) for three consecutive days. A control group of four female mice was treated with the vehicle propylene glycol only.
The historical positive control, α-Hexylcinnamaldehyde was found to be a potential skin sensitizer in the LLNA tests and an EC3 value of 11.2 % was derived. The test system was therefore considered to be valid.
The Stimulation Index (S.I) of 1.2, 0.9, 1.0, 1.3 and 1.4 were determined with the test substance at concentrations of 2.5 %, 5 %, 10 %, 25 % and 50 % (w/v), respectively, in propylene glycol.
All treated animals survived the scheduled study period. Neither clinical signs on the ears of the animals nor systemic findings were observed during the study period. No abnormal findings were observed in the size or other physical features of the draining lymph nodes.
Under the test conditions, the test material is not classified as skin sensitiser.
An other study (Huntingdon, 1979) performed on the registered substance in rats was non-GLP and was of poor quality (Klimish score = 3) but supports the results of the key study.
CONCLUSION: Not sensitising
Moreover, in the HERA report on Esterquats of November 2009, the result of a GPMT performed by Unilever on Hamburg Ester Quat (HEQ), an other analogue of the registered substance, is "Not a sensitizer".
Reference:HERA (2009). Human and Environmental Risk Assessment on Ingredients of Household Cleaning Products (HERA), Avenue Herrmann Debroux ISA, B-1160 Brussels Belgium. Edition 1.0 November 2009. Esterquats Human Health Risk Assessment Report. <http://www.heraproject.com/files/17-HH-HERA-EQ-HH-TM-finalDraft-24Nov%20web.pdf>.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Harmonized classification:
The substance has no harmonized classification according to the Regulation (EC) No. 1272/2008.
Self-classification:
Based on the available data, the substance is not classified as skin sensitizer according to the Annex VI of the Regulation (EC) No. 1272/2008 (CLP) and according to the GHS.
No data was available for respiratory sensitisation. However, this substance is not a skin sensitizer, therefore according to Figure R.7.3 -2 of the Chapter R.7 (V 4.1 - October 2015) the chemical is not considered as a respiratory sensitizer.
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