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EC number: 946-967-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study initiation date - 02 November 1993; Experiment start and date - 10 November 1993; Study completion date - 19 November 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- yes
- Remarks:
- -Deionised water instead of dest. water for the stock solution. -Preparation of the inoculum : higher sludge weight after the washing procedure (Sludge concentrations in the test according to the guidelines). - 4 instead of 5 test concentrations
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Code number: FAT 31016/P
- EN-Nr.: 414154.32
- Purity: 95 %
- Appearance: solid
- Solubility: 40 g/L (in water)
- Storage: room temperature
- Expiration date: 07/98 - Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Organism: Activated sludge of a communal sewage treatment plant (ARA-Birsig Therwil)
- Sludge pretreatment: 3 times washing with tap water and addition of synthetic sewage (a day before the main test) - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Test temperature:
- 21.5 °C
- pH:
- 7.8 - 8.0
- Dissolved oxygen:
- O2-consumption (in cm) 10 mg/l: 3.9, 32 mg/l: 2.4, 100 mg/l 0.7 and 320 mg/l: 0.4
- Nominal and measured concentrations:
- 320, 100, 32 and 10 mg/l of the test substance
- Details on test conditions:
- - Temperature: 21.5 °C
- Sludge dry weight: 1.50 g/l
- Test volume: 100 ml
- Test duration: 3h
- Estimation technique: O2 - consumption, measured with an oxygen sensitive electrode system: OXI DIGI 530 (SAV : 00 109)
- Aeration: 0.1 - 0.2 l/min by pasteur-pipette
- pH of sludge: 7.9 before the test beginning - Reference substance (positive control):
- yes
- Remarks:
- 3,5-Dichlorophenol
- Key result
- Duration:
- 3 h
- Dose descriptor:
- IC50
- Effect conc.:
- 21 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Results with reference substance (positive control):
- The IC50 (3 h) of the reference substance 3,5-Dichlorophenol: 8.0 mg/l
- Validity criteria fulfilled:
- yes
- Conclusions:
- The IC50 (3 h) of the test substance FAT 31016/P was determined to be 21 mg/l.
- Executive summary:
The toxicity of FAT 31016/P to activated sludge was determined in a 3-hours respiration inhibition test according to the OECD Guideline No. 209, and to the EEC Method No. L 133/118. The test was performed in compliance with the Good Laboratory Practice (GLP) Regulations of Switzerland. The test substance concentrations tested were 320, 100, 32 and 10 mg/l. The % inhibitions observed at test concentrations 320, 100, 32 and 10 mg/l were 93.02, 84.88, 61.63 and 29.07, respectively. Hence, the IC50 (3 h) of the test substance FAT 31016/P was determined to be 21 mg/l.
Reference
Table: % inhibition observed for test concentrations
Test substance (mg/l) |
% inhibition |
320 |
93.02 |
100 |
84.88 |
32 |
61.63 |
10 |
29.07 |
Description of key information
The IC50 (3 h) of the test substance FAT - 31016/P was determined to be 21 mg/l.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 21 mg/L
Additional information
The toxicity of FAT - 31016/P to activated sludge was determined in a 3-hours respiration inhibition test according to the OECD Guideline No. 209, and to the EEC Method No. L 133/118. The test was performed in compliance with the Good Laboratory Practice (GLP) Regulations of Switzerland. The test substance concentrations tested were 320, 100, 32 and 10 mg/l. The % inhibitions observed at test concentrations 320, 100, 32 and 10 mg/l were 93.02, 84.88, 61.63 and 29.07, respectively. Hence, the IC50 (3 h) of the test substance FAT - 31016/P was determined to be 21 mg/l. In another study, the toxicity of FAT 31016/C was to be 50 mg O2/g
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