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EC number: 201-969-4 | CAS number: 90-15-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Not all validity criteria of OECD 203 can be thoroughly verified as there are to little detail on the test conditions. Flow-through conditions were applied and the test set up was according to "committee on methods of toxicity tests with aquatic organisms (Anon 1975)". Test conditions are stated but without any description of the variation over time. There were no mortalities in the controls and the dissolved oxygen concentrations were above 60%.
- Principles of method if other than guideline:
- - Principle of test: Fish (3 x n= 10) were exposed for 96 hours to five concentrations of 1 naphthol, plus controls and 96 hour LC50 were derived
- Short description of test conditions: Fish were exposed in a flow through system folowing the guidelines in the report "Commitee on methods of toxicity tests with aquatic organism (Anon, 1975)"
- Parameters analysed / observed: Lethality - GLP compliance:
- no
- Analytical monitoring:
- no
- Remarks:
- Concentrations in the dosing reservoirs were confirmed at thefirst 6 hours of the exposure with a colorimetric analysis.
- Vehicle:
- yes
- Remarks:
- acetone
- Details on test solutions:
- Standard solutions of the toxicants (100 mg/ml and 10 mg/ml) were prepared in acetone. The control fish received an equal quantity of acetone.
- Test organisms (species):
- other: Catla catla, Mystus vittatus, M. cavasius and Anabas testudineus
- Details on test organisms:
- Four species of fish were tested
TEST ORGANISMS
- Latin names: Catla catla, Mystus vittatus, M. cavasius, Anabas testudineus
- Common name: Major (Indian) carp, Striped dwarf catfish, NA, climbing perch
- Length at study initiation (length definition, mean, range and SD):1-1.25, 4.5-6, 5-5.6, 4-5.5
- Weight at study initiation (mean and range, SD): 0.3, 3.5, 4, 8
ACCLIMATION
- Acclimation stated but period not specified
- Acclimation conditions (same as test or not): same as test
- Type and amount of food during acclimation: None
- Health during acclimation (any mortality observed):< 5% mortality
FEEDING DURING TEST
None - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 152 mg/L
- Test temperature:
- 28+- 2C
- pH:
- 8.4
- Dissolved oxygen:
- 8-10 ppm
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.33 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks:
- M. cavasius
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 4.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks:
- C. catla
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks:
- M. vittatus
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks:
- A. testutus
- Details on results:
- No mortality in the controls
- Sublethal observations / clinical signs:
Species LC50 95% Confidence limits Catla catla 4.3 4.2 -4.4 Mystus vittatus 1.1 0.9 -1.4 Mystus cavasius 0.33 0.25 -0.4 Anabas testutus 3 2.7 -3.4 - Validity criteria fulfilled:
- yes
- Conclusions:
- The test procedure follows an older report from the Environmental Protection Agency (Anonymous (1976) Committee on methods of toxicity tests with fish, macroinvertebrates and amphibians. Environmental Protection Agency, Oregon, 61 pp.
Not all validity criteria of OECD 203 can be thoroughly verified as there are to little detail on test conditions. However it is clearly stated that there were no mortalities in the controls and the dissolved oxygen concentrations were above 60%. Flow-through conditions were applied and the test conditions are described but without any description of the variation. - Executive summary:
The acute toxicity of 1-naphthol, to four species of fish was studied. The calculated 96 h LC50 values of 1-naphthol for Catla catla, Anabas testudineus, Mystus cavasius and Mystus vittatus were 4.3, 3, 0.33 and 1.1 mg/L respectively.
Reference
Description of key information
Three reliable (Klimish rating 2) studies are available for the short-term toxicity of 1-naphthol to fish. The catfish Mystus cavasius had a 96 hour LC50 of 0.33 mg/L ( 95% confidence limits 0.25 -0.4 mg/L) as measured by a flow-through exposure study (Tilak et al 1981) is noted as key. The 96 hour LC50 for the additional four fish species ranged from 1.1 – 4.63 mg/L (Geiger et al 1984, Holcombe et al 1984, Tilak et al 1981) are noted as supporting.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.33 mg/L
Additional information
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