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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: Geranyl propionate
Author:
Edited by D. L. J. OPDYKE
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology, Volume 12, Issues 7–8, December 1974, Page 897

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the irritation property of geranyl propionate by skin irritation method on rabbit skin.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Geranyl propionate
EC Number:
203-344-1
EC Name:
Geranyl propionate
Cas Number:
105-90-8
Molecular formula:
C13H22O2
IUPAC Name:
geranyl propionate
Test material form:
liquid
Details on test material:
- Name of test material : (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate
- common name : Geranyl propionate
- Molecular formula : C13H22O2
- Molecular weight : 210.3148 g/mol
- Smiles notation : CCC(=O)OC\C=C(/C)\CCC=C(C)C
- InChl : 1S/C13H22O2/c1-5-13(14)15-10-9-12(4)8-6-7-11(2)3/h7,9H,5-6,8,10H2,1-4H3/b12-9+
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material : (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate
- common name : Geranyl propionate
- Molecular formula: C13H22O2
- Molecular weight: 210.3148 g/mol
- Smiles notation : CCC(=O)OC\C=C(/C)\CCC=C(C)C
- InChl : 1S/C13H22O2/c1-5-13(14)15-10-9-12(4)8-6-7-11(2)3/h7,9H,5-6,8,10H2,1-4H3/b12-9+
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data available

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact and abraded
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
undiluted
Duration of treatment / exposure:
24 hours
Observation period:
24 hours
Number of animals:
no data available
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
no signs of irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Geranyl propionate was not irritating to rabbit skin after 24 hours exposure.
Executive summary:

A skin irritation study was performed in rabbits to assess the irritation potential of Geranyl propionate. Geranyl propionate was applied full strength to the intact and abraded skin of rabbits under occlusion for 24 hours.Geranyl propionate was not irritating to rabbit skin after 24 hours exposure.