Registration Dossier
Registration Dossier
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EC number: 285-083-3 | CAS number: 85029-58-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 Oct. 1973 to 03 Sept. 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- According to D.N. Noakes and D.M. Sanderson: A Method for Determing the Dermal Toxicity of Pesticides. Brit. J. Ind. Med. 26, 59, 1969
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Amines, C10-14-branched and linear alkyl, bis[2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)]chromate(1-)
- EC Number:
- 285-083-3
- EC Name:
- Amines, C10-14-branched and linear alkyl, bis[2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)]chromate(1-)
- Cas Number:
- 85029-58-9
- Molecular formula:
- C34H24CrN8O6.C10-14H21-29NH2
- IUPAC Name:
- reaction mass of: branched and linear(C10-C14)ammonium , bis[2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)]chromate(1-)
- Details on test material:
- The substance was formerly identified as: 73297-13-9 / 615-953-3 / Chromate(1-), bis[2-[2-[4,5-dihydro-3-methyl-5-(oxo-κO)-1-phenyl-1H-pyrazol-4-yl]diazenyl-κN1]benzoato(2-)-κO]-, hydrogen, compd. with 1-tridecanamine (1:1:1)
Constituent 1
- Specific details on test material used for the study:
- Name of the test substance used in the study report: Neozapongelb R (TDA) Chromium-1.2-complex
old CAS 73297-13-9
new CAS 85029-58-9, same structure
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weight: males 135 g, females 121 g
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- A 50% test substance concentration was used
Application area: 50 cm2 (average) - Duration of exposure:
- 24 h
- Doses:
- 2500 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and local skin findings
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: During and after application as well as during the 14-day observation period the animals were vivacious.
- Gross pathology:
- Nothing abnormal detected
- Other findings:
- Local findings:
- After 24 hours all animals showed substance residues (light brown), reddening not visible
- After 8 days: no local effects observed in all animals, yellowish substance residues
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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