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Diss Factsheets
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EC number: 279-506-0 | CAS number: 80584-92-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982-09-06 - 1982-09-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: EPA guideline: Paragraph 163.81-5 "Primary dermal irritation study". Federal Register, Vol 43 No. 163, August 22, 1978
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- 6,6',6''-(1,3,5-triazine-2,4,6-triyltriimino)trihexanoic acid, compound with 2,2',2''-nitrilotriethanol (1:3)
- EC Number:
- 279-506-0
- EC Name:
- 6,6',6''-(1,3,5-triazine-2,4,6-triyltriimino)trihexanoic acid, compound with 2,2',2''-nitrilotriethanol (1:3)
- Cas Number:
- 80584-92-5
- Molecular formula:
- C21H36N6O6.3C6H15NO3
- IUPAC Name:
- 6,6',6''-(1,3,5-triazine-2,4,6-triyltriimino)trihexanoic acid, compound with 2,2',2''-nitrilotriethanol (1:3)
- Details on test material:
- - Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, 4414 Fuellinsdorf, Switzerland
- Weight at study initiation: 2 - 3 kg
- Housing: individually in metal cages
- Diet: ad libitum (NAFAG, No. 814 Tox, NAFAG AG, Gossau, Switzerland)
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3
- Humidity (%): 55±15
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Untreated skin site served as a control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 mL - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 7 days
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: entire back and the flank
- Type of wrap if used: impermeable patches fastened with adhesive tape
SCORING SYSTEM:
Erythyma and eschar formation
No erythema 0
Very slight erythema (barely perceptible 1
Well defined erythema 2
Moderate to severe erythema 3
Severe erythema (beet redness) to slight eschar formation (injuries in depth) 4
Total possible erythema score 4
Edema formation
No edema 0
Very slight edema (barely perceptible) 1
Slight edema (edges of area well defined by definite raising) 2
Moderate edema (raised more than 1 mm) 3
Severe edema (raised more than 1 mm and extending beyond area of exposure 4
Total possible edema score 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.77
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Remarks on result:
- other: intact skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.94
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.39
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: abraded skin
- Irritant / corrosive response data:
- The test substance caused slight irritation to the intact and abraded skin (please refer to the table at "Any other information on results incl. tables" showing the single results of the intact skin).
Any other information on results incl. tables
Irritation parameter |
Basis |
Time point |
Score |
Max. score |
Reversibility |
Remarks |
Erythema score |
Animal #1 |
24, 48, 72 hours |
0.66 |
4 |
Fully reversible after 48 hours |
Intact skin |
Edema score |
Animal #1 |
24, 48, 72 hours |
0 |
4 |
- |
Intact skin |
Erythema score |
Animal #2 |
24, 48, 72 hours |
0.33 |
4 |
Fully reversible after 48 hours |
Intact skin |
Edema score |
Animal #2 |
24, 48, 72 hours |
0 |
4 |
- |
Intact skin |
Erythema score |
Animal #3 |
24, 48, 72 hours |
0.66 |
4 |
Fully reversible after 48 hours |
Intact skin |
Edema score |
Animal #3 |
24, 48, 72 hours |
0.66 |
4 |
Fully reversible after 48 hours |
Intact skin |
Erythema score |
Animal #4 |
24, 48, 72 hours |
1 |
4 |
Fully reversible after 72 hours |
Intact skin |
Edema score |
Animal #4 |
24, 48, 72 hours |
1 |
4 |
Fully reversible after 72 hours |
Intact skin |
Erythema score |
Animal #5 |
24, 48, 72 hours |
1.33 |
4 |
Fully reversible after 72 hours |
Intact skin |
Edema score |
Animal #5 |
24, 48, 72 hours |
0.33 |
4 |
Fully reversible after 48 hours |
Intact skin |
Erythema score |
Animal #6 |
24, 48, 72 hours |
1.33 |
4 |
Fully reversible after 72 hours |
Intact skin |
Edema score |
Animal #6 |
24, 48, 72 hours |
0.33 |
4 |
Fully reversible after 48 hours |
Intact skin |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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