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EC number: 212-094-2 | CAS number: 762-16-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The oral LD50 is > 5000 mg/kg bw. no further information available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP guideline type study, limited details but sufficient, no COA but test article is identified withing text of report.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult albino rats from the Institute's colony (Wistar
derived; males 192 to 255 g and females 157 to 225 g body
weight) were used. They were housed in groups of five in
screen-bottomed stainless steel cages, ln a well-ventilated
room maintained at 25 C. Before dosing the rats were
fasted overnight. - Route of administration:
- oral: gavage
- Vehicle:
- other: Shellsol T
- Details on oral exposure:
- After some preliminary observations the test material was
given by gavage as a 50% (w/v) suspension in Shellsol T,
to groups of ten males and ten females in one single dose
of 10 ml per kg body weight, which is equivalent to 5 g
test material per kg body weight.
Since the LD50 of Shellsol T was stated to be about 8 ml/kg
body weight, no higher dose of the suspension was considered
to be tolerated. After treatment the rats received stock
diet and tap water ad libitum. They were observed for signs
of intoxication during a 14-days period, after which
autopsies were carried out on the survivors. - Doses:
- 5g/kg
- No. of animals per sex per dose:
- Ten
- Control animals:
- no
- Details on study design:
- After some preliminary observations the test material was
given by gavage as a 50% (w/v) suspension in Shellsol T,
to groups of ten males and ten females in one single dose
of 10 ml per kg body weight, which is equivalent to 5 g
test material per kg body weight.
Since the LD50 of Shellsol T was stated to be about 8 ml/kg
body weight, no higher dose of the suspension was considered
to be tolerated. After treatment the rats received stock
diet and tap water ad libitum. They were observed for signs
of intoxication during a 14-days period, after which
autopsies were carried out on the survivors. - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no mortalities
- Mortality:
- None
- Clinical signs:
- other: None observed
- Gross pathology:
- Macroscopic examination revealed no treatment-related gross alterations.
- Interpretation of results:
- not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of dioctanoyl peroxide to rats was greater than 5 g/kg.
- Executive summary:
The test article was evaluated for acute oral toxicity to rats at a limit dose of 5 g/kg. No moralities, clinical signs of toxicity or macroscopic findings were reported.
The acute oral LD50 to rats was greater than 5 g/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- One study is availble, K2. It was performed pre-GLP.
Additional information
Justification for classification or non-classification
Based on the available information the subsatnce is not classified for acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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