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EC number: 605-718-3 | CAS number: 174350-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09/05/2007-12/08/2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- yes
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia
- Strain/clone: Daphnia Magna
- Source: in house
- Age of parental stock: younger than 24 hours
- Feeding during test: no
ACCLIMATION
- Acclimation period: 5 days
- Acclimation conditions: same as test (controlled environment room, pH 7.9+/-0.3)
- Type and amount of food: green algea (Scenedesmus subspicatus)
- Health during acclimation: no mortality observed
At the start of the experimental phase 5 Daphnia magna were placed in each test vessel containing 10 mL reconstituted water with or without test material. The test vessels were left open. - Test type:
- other: open-static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Hardness:
- 14o dH (about 250 mg/L CaCO3)
- Test temperature:
- 18 – 22 °C
- pH:
- 7.9 +/- 0.3
- Dissolved oxygen:
- at least 90 %
- Nominal and measured concentrations:
- Nominal 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: open static
- Material: test item in reconstituted water
- Aeration: 24 hours after preparation
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): 4
- Biomass loading rate: -
-TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted according to ELENDT (1990)
- Macro nutrients: mg/L
CaCl2 x 2H2O: 293.80
MgSO4 x 7H2: 123.30
NaHCO3: 64.80
KCl: 5.80
Na2SiO3 x 9H2O: 10.00
NaNO: 30.27
KH2PO: 40.14
K2HPO: 40.18
- Trace elements: mg/L
B: 0.5000
Fe: 0.2000
Mn: 0.1000
Li, Rb and Sr: 0.0500
Mo: 0.0250
Br: 0.0125
Cu and Zn: 0.0063
Co and I: 0.0025
Se: 0.0010
V: 0.0003
- Macro nutrients
Na2EDTA x 2H2O: 2.50
- Vitamins µg/L
Thiamine: 75.00
B12: 1.00
Biotin: 0.75
- Total organic carbon: --
- Particulate matter: --
- Metals: --
- Pesticides: --
- Chlorine: --
- Alkalinity: --
- Ca/mg ratio: --
- Conductivity: --
- Culture medium different from test medium: no
- Intervals of water quality measurement: 48 h
OTHER TEST CONDITIONS
- Adjustment of pH: 7.9
- Photoperiod: 16h light / 8h dark
- Light intensity: --
References: ELENDT, B.-P. Selenium deficiency in Crustacea. An ultrastructural approach to antennal damage in Daphnia magna Straus.Protoplasma 154, 25-33, 1990 - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- In this open static test system, Daphnia magna exposed to a nominal concentration of 100 mg/L revealed no biological effects.
- Results with reference substance (positive control):
- Potassium dichromate: 24 h EC50 0.95 (0.87-1.04) mg/L; 48 h EC50 0.74 (0.68-0.81) mg/L
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test material showed no aquatic toxicity, thus the 48 hours NOEC and EC50 to Daphnia magna for the test item are > 100 mg/L (nominal).
- Executive summary:
Purpose
The purpose of this assay was to identify the aquatic toxicity potential of the test material in Daphnia magna to provide a rational basis for hazard estimation for the test item in aquatic environments.
Study design
For this purpose, juvenile Daphnia magna were exposed to an aqueous test material preparation over 48 hours, under defined conditions. The GLP study was performed as a limit test according to OECD 202.
Results
The following results have been obtained:
Nominal concentration Immobilization immobilized / exposed
[g/L]
24 hours
48 hours
0.0
0/20
0/20
0.1
0/20
0/20
Daphnia magna exposed to an aqueous preparation of the nominal concentration of 100 mg/L of test item were not affected.
For the test material the following EC50 values for Daphnia magna were determined:
24 h EC50 > 0.1 g/L (nominal > 100 mg/L)
48 h EC50 > 0.1 g/L (nominal > 100 mg/L)
NOEC > 0.1 g/L (nominal)
LOEC > 0.1 g/L (nominal)
Conclusions
Under the given experimental conditions, the test material showed no aquatic toxicity. The 48 hours NOEC and EC50 to Daphnia magna are > 100 mg/L (nominal).
Reference
Description of key information
The test material showed no aquatic toxicity, thus the 48 hours NOEC and EC50 to Daphnia magna for the test item are > 100 mg/L (nominal).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 100 mg/L
Additional information
Purpose
The purpose of this assay was to identify the aquatic toxicity potential of the test material in Daphnia magna to provide a rational basis for hazard estimation for the test item in aquatic environments.
Study design
For this purpose, juvenile Daphnia magna were exposed to an aqueous test material preparation over 48 hours, under defined conditions. The GLP study was performed as a limit test according to OECD 202.
Results
The following results have been obtained:
Nominal concentration Immobilization immobilized / exposed | ||
[g/L] | 24 hours | 48 hours |
0.0 | 0/20 | 0/20 |
0.1 | 0/20 | 0/20 |
Daphnia magna exposed to an aqueous preparation of the nominal concentration of 100 mg/L of test item were not affected.
For the test material the following EC50 values for Daphnia magna were determined:
24 h EC50 > 0.1 g/L (nominal > 100 mg/L)
48 h EC50 > 0.1 g/L (nominal > 100 mg/L)
NOEC > 0.1 g/L (nominal)
LOEC > 0.1 g/L (nominal)
Conclusions
Under the given experimental conditions, the test material showed no aquatic toxicity. The 48 hours NOEC and EC50 to Daphnia magna are > 100 mg/L (nominal).
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