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EC number: 500-039-8 | CAS number: 25322-69-4 1 - 4.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
No data is available for ‘propane-1,2-diol, propoxylated’. Comparing the available aquatic toxicity data, the QSAR information and the constitution of ‘propane-1,2-diol, propoxylated’, it seems likely that the aquatic toxicity is expected to be similar to di- and tripropylene glycol. As from the QSAR data it is observed that dipropylene glycol has the tendency to be more toxic than tripropylene glycol in any case the lowest effect concentration of the two substances will be considered. Consequently, the results for di and tripropylene glycol were taken for read across and the lowest effect concentration was considered.
Short term toxicity to fish:
No experimental data are available for ‘propane-1,2-diol, propoxylated’. Based on the 96-h LC50 of the structurally related analogue and constituent tripropylene glycol (> 1000 mg/L), it can be assumed that the 96-h LC50 of ‘propane-1,2-diol, propoxylated’ is > 1000 mg/L. This is supported by calculations with the ECOSAR QSAR which indicate a 96h-LC50 values for the components well in excess of this.
Long-term toxicity to fish:
Long-term exposure of fish is not considered relevant as the substance is biodegradable. Furthermore, the short-term toxicity test shows very low toxicity to fish. As the QSAR for long-term toxicity to fish is high (30-d ChV is predicted to be in the range 1800 -2100mg/L), chronic toxicity to fish is not expected. Therefore, the long-term toxicity test with fish does not seem necessary to perform.
Short-term toxicity to aquatic invertebrates:
No experimental data are available for ‘propane-1,2-diol, propoxylated’. However, for the structural analogues and constituents mono-, di- and tripropylene glycol data are available. Based on the lowest 48h-EC50 of >100 mg/L (for dipropylene glycol), it can be assumed that the 48h-EC50 for ‘propane-1,2-diol, propoxylated’ is > 100 mg/L. This is supported by calculations with ECOSAR v1.11 which indicate a 48h-EC50 in the range 11000 -12500 mg/l.
Long-term toxicity to aquatic invertebrates:
Long-term exposure of aquatic invertebrates is not considered relevant as the substance is ready biodegradable. Furthermore, the long-term toxicity test with the structural analogues mono- and tripropylene glycol show very low long term toxicity to aquatic invertebrates (7d NOEC of the order of 13000 mg/L to Ceriodaphnia duba and 21d-NOEC of > 1000 mg/L to Daphnia magna, respectively). Based on these results, it can be assumed that the 21d-NOEC of ‘propane-1,2-diol, propoxylated’ is > 100 mg/L. This is supported by calculations with ECOSAR v1.00 which indicate a 16d-ChV in the range 550 -650mg/L. Therefore, a long-term toxicity test with aquatic invertebrates is not considered necessary.
Toxicity to aquatic algae:
No experimental data are available for ‘propane-1,2-diol, propoxylated’. However, for the structural analogues and constituents mono-, di- and tripropylene glycol data are available. Based on the lowest 72h-EC50 of >100 mg/L (for dipropylene glycol), it can be assumed that the 72h-EC50 for ‘propane-1,2-diol, propoxylated’ is > 100 mg/L. This is supported by calculations with ECOSAR v1.00 which indicate a 72h-EC50 value in the range 3000 -4000 mg/L.
Toxicity to micro-organisms:
No experimental data are available for ‘propane-1,2-diol, propoxylated’. However, for the structural analogues and constituents mono-, di- and tripropylene glycol data are available. Based on the lowest value, the 3h-NOEC of 1000 mg/L (for tripropylene glycol), it can be assumed that the 3h-NOEC for ‘propane-1,2-diol, propoxylated’ is 1000 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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