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Diss Factsheets
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EC number: 946-569-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Pre-GLP study with following restrictions: observation period was 7 days only; rationale for dose selection was not provided (highest tested dose was 10000 mg/kg bw); body weight and necropsy examinations were not performed
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- Observation period of 7 days only
- Deviations:
- not applicable
- Principles of method if other than guideline:
- In an acute oral toxicity study, a single dose of 2500, 5000 or 10000 mg/kg bw of the test substance suspended in 40% ethanol was given to groups of male rats (6/dose). Observations for toxic symptoms and mortality were made for 7 days, and the survivors were sacrificed without autopsy.
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Resinoid of Styrax benzoin (Styracaceae) obtained from exudate by ethanol extraction
- EC Number:
- 946-569-7
- IUPAC Name:
- Resinoid of Styrax benzoin (Styracaceae) obtained from exudate by ethanol extraction
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Label of test material: Compound HKS (Benzoin)
- Date of receipt: 07 January 1970
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 150-250 g
- Fasting period before study: 16 hours prior to dosing
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- ethanol
- Details on oral exposure:
- None
- Doses:
- 2500, 5000 and 10000 mg/kg bw suspended in 40% ethanol
- No. of animals per sex per dose:
- 6 males per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Observations for toxic symptoms and mortality were made for 7 days. Cumulative mortality was recorded immediately after dosing and at 1 and 4 hours, and then once daily for 7 days.
- Necropsy of survivors performed: No - Statistics:
- No data
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- In 10000 mg/kg bw group, 2 animals died within a day. No animal died in other groups.
- Clinical signs:
- No principal toxic effect was noted.
- Body weight:
- Not applicable
- Gross pathology:
- Not applicable
- Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the test conditions, the oral LD50 of the test substance is considered as >5000 mg/kg bw in rats.
- Executive summary:
In an acute oral toxicity study, a single dose of 2500, 5000 or 10000 mg/kg bw of the test substance suspended in 40% ethanol was given to groups of male rats (6/dose). Observations for toxic symptoms and mortality were made for 7 days, and the survivors were sacrificed without autopsy.
In 10000 mg/kg bw group, 2 animals died within a day. No other toxic effect was noted at any dose level.
Rat Oral LD50 >5000 mg/kg bw
Under the test conditions, the oral LD50 of the test substance is considered as >5000 mg/kg bw in rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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