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EC number: 235-166-5 | CAS number: 12108-13-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not mentioned
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed comparable to OECD 402 with acceptable deviations.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- No information on the sex of the animals or environmental conditions. Only four animals were used, two of which had their skin abraded prior to exposure.
- GLP compliance:
- no
- Remarks:
- Test conducted prior to GLP guidelines.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tricarbonyl(methylcyclopentadienyl)manganese
- EC Number:
- 235-166-5
- EC Name:
- Tricarbonyl(methylcyclopentadienyl)manganese
- Cas Number:
- 12108-13-3
- Molecular formula:
- C9H7MnO3
- IUPAC Name:
- tricarbonyl(methyl-η5-cyclopentadienyl)manganese
- Details on test material:
- - Name of test material: methylcyclopentadienyl manganese tricarbonyl
- Physical state: Dark amber liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: the laboratory stock colony
- Age at study initiation: No data
- Weight at study initiation: 3.323-4.875 Kg
- Fasting period before study: No
- Housing: Individually
- Diet: ad libitum
- Water : ad libitum
- Acclimation period: not relevant, animals bred in the laboratory
ENVIRONMENTAL CONDITIONS
No data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: upper back area
- % coverage: no data
- Type of wrap if used: impervious band
REMOVAL OF TEST SUBSTANCE
- Washing: no data
- Time after start of exposure: N.A.
TEST MATERIAL
No data.
- Duration of exposure:
- 24 hours.
- Doses:
- 112, 126, 141 and 158 mg/kg
- No. of animals per sex per dose:
- 4 animals per dose, (2 with abraded skin, 2 with intact skin) no information on the sex.
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Frequent observations after dosing and daily for 14 days for illness and mortality. Body weighting were recorded on days 0, 3, 7, 10 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight and skin reactions. - Statistics:
- Dermal LD50 calculated according to the methods of Litchfield and Wilcoxon, 1949.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 140 mg/kg bw
- 95% CL:
- 122 - 159
- Mortality:
- Number of Dead/Dosed per concentration applied:
- 112 mg/kg: 0/4
- 126 mg/kg: 1/4
- 141 mg/kg: 2/4
- 158 mg/kg: 3/4 - Clinical signs:
- other: General appearance and behaviour of the rabbits were not effected.
- Gross pathology:
- Gross observations of the viscera reveal congested organs with blood tinged urine at the higher dose levels. Two rabbits with respiratory ailments and one with kidney stones were believed to be non-compound related. A general pattern of red discoloration of the kidneys is present at all dose levels. For detailed information see table 2.
Any other information on results incl. tables
Table 1 - Individual body weights
Rabbit No. |
Mg/kg |
Day 0 |
3 |
7 |
10 |
14 |
216 Abraded |
112 |
4.070 |
3.987 |
3.863 |
3.965 |
4.002 |
217 A. |
4.412 |
4.116 |
4.025 |
4.102 |
4.233 |
|
212 Intact |
4.730 |
4.503 |
4.470 |
4.526 |
4.670 |
|
214 I. |
4.875 |
4.675 |
4.600 |
4.675 |
4.827 |
|
|
||||||
204 A. |
126 |
4.525 |
|
|||
294 A. |
3.345 |
3.506 |
3.640 |
3.407 |
3.504 |
|
228 I. |
3.323 |
3.4199 |
3.475 |
3.168 |
3.273 |
|
306 I. |
3.660 |
3.696 |
3.743 |
3.969 |
4.105 |
|
|
||||||
218 A. |
141 |
3.595 |
3.326 |
3.189 |
3.195 |
3.357 |
219 A. |
4.070 |
|
||||
220 I. |
4.465 |
|||||
231 I. |
3.870 |
3.813 |
3.765 |
3.791 |
3.920 |
|
|
||||||
183 A. |
158 |
4.185 |
4.132 |
4.006 |
4.085 |
4.108 |
205 A. |
3.780 |
|
||||
247 I. |
4.141 |
3.646 |
|
|||
203 I. |
4.085 |
|
A - abraded skin
I - intact skin
Table 2 - Clinical signs and gross pathology
Rabbit # |
mg/kg |
Daily observations |
Necropsy |
216 Abraded |
112 |
None noted |
None noted. |
217 A. |
None noted |
Liver margin swollen |
|
212 Intact |
None noted |
Kidneys congested. |
|
214 I. |
None noted |
Kidneys congested. |
|
|
|||
204 A. |
126 |
Died, Day 2 |
Lungs discolored. Red tinged urine in bladder. Red tinged kidney – cortex red. |
294 A. |
None noted |
Red tinged kidney – cortex red. |
|
228 I. |
None noted |
Renal calculi. Red tinged kidney, small with much scar tissue. |
|
306 I. |
None noted |
Red tinged kidney – spotted red. |
|
|
|||
218 A. |
141 |
None noted |
Kidneys discolored. |
219 A. |
Died, Day 3 |
Lungs and liver discolored; small intestine contains yellow fluid. |
|
220 I. |
Died, Day 3 |
Lungs, liver and kidney discolored; small intestine contains yellow fluid. |
|
231 I. |
None noted |
Respiratory infection |
|
|
|||
183 A. |
158 |
Died within 24 hours |
Lungs dark red, liver spotted red. Spleen discolored red. Kidneys abnormal shape and nodular. Small intestine filled with yellow fluid. |
205 A. |
None noted |
Respiratory disease. Spleen appears swollen; kidneys discolored red. |
|
247 I. |
Died, Day 3 |
Lungs, liver, spleen and kidneys discolored red. Urine red tinged and contains clotted blood. Small intestine filled with yellow fluid. |
|
203 I. |
Died, Day 2 |
Lungs, liver, spleen and kidneys discolored red. Small intestine filled with yellow fluid. |
Table 3 - Daily observations of skin
Rabbit No. |
Mg/kg |
Days |
|||||||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
||
216 A. Erythema Edema |
112 |
1 2 |
1 1 |
1 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
217 A. Erythema Edema |
2 2 |
1 1 |
1 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
|
212 I. Erythema Edema |
2 2 |
1 1 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
|
214 I. Erythema Edema |
1 1 |
1 1 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
|
204 A. Erythema Edema |
126 |
1 2 |
1 1 |
|
|||||||||||
294 A. Erythema Edema |
1 1 |
1 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
|
228 I. Erythema Edema |
1 1 |
1 1 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
|
306 I. Erythema Edema |
1 2 |
1 1 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
|
218 A. Erythema Edema |
141 |
1 2 |
1 1 |
1 0 |
1 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
219 A. Erythema Edema |
2 1 |
1 1 |
|
||||||||||||
220 I. Erythema Edema |
1 1 |
1 1 |
|||||||||||||
231 I. Erythema Edema |
1 2 |
1 1 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
|
183 A. Erythema Edema |
158 |
2 2 |
1 1 |
1 0 |
1 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
205 A. Erythema Edema |
|
||||||||||||||
247 I. Erythema Edema |
1 1 |
1 1 |
|
||||||||||||
203 I. Erythema Edema |
1 0 |
|
Evaluation of skin reaction
Erythema and eschar formation:
No erythema 0
Very slight erythema 1
Well-defined erythema 2
Moderate to severe erythema 3
Severe erythema (beet redness to slight
eschar formation (injuries in depth) 4
Edema formation:
No edema 0
Very slight edema 1
Slight edema 2
Moderate edema 3
Severe edema 4
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information H310: Fatal in contact with skin Criteria used for interpretation of results: EU
- Conclusions:
- Evidence of congestion or possible internal hemorrhage are present in the major organs. Blood tinged urine at the higher dose levels was noted.
Mortality occurred within 24 hours and up to 3 days after application. Dermal reaction were limited to slight to well defined erythema and slight edema persisting to maximum 4 days after application. The dermal LD50 was calculated at 140 mg/kg-bw (95% CL of 122-159 mg/kg-bw). - Executive summary:
In an acute dermal toxicity study, groups of 4 mature healthy New Zealand albino rabbits (2 with abraded skin and 2 with intact skin) were dermally exposed to mmt for 24 hours at doses of 112, 126, 141 or 158 mg/kg bw. Animals were observed for 14 days after dosing. Although the general appearance and behavior of the animals was not altered, dermal reactions like erythema and a slight edema were seen with symptoms subsiding in 1-4 days. A pathological observations indicating evidence of congestion or possible internal hemorrhage were present in the major organs. Blood tinged urine at the higher dose levels was also seen.
Dermal LD50= 140 mg/kg bw (95% C.I. 122-159 mg/kg). This LD50 would result in mmt being classified as a Category 2 Acute Dermal Toxicant, H310: Fatal in contact with skin per EC/1272/2008.
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