2,2'-methylenebis[6-cyclohexyl-p-cresol]

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Study period:

1959-03-16 - 1959-09-07

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Study conducted prior to GLP, no guideline followed as none was available in 1959, deficiencies in documentation, no analytical determination of the test concentration, mostly no standard species used.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1959

Report date:

1959

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Animals were exposed over 4h to the vaporated test item

GLP compliance:

no

Remarks:

test conducted prior to GLP implementation

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan

IUPAC Name:

2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan

Test material form:

other: vaporated solid

Details on test material:

- Name of test material (as cited in study report): 2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan
- Substance type: pure substance

Test animals

Species:

other: cat, rabbit, guinea pig, rat, mouse

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

1 cat, 1 rabbit, 1 guinea pig, 2 rats and 4 mice were exposed.

Administration / exposure

Route of administration:

inhalation: mist

Type of inhalation exposure:

whole body

Vehicle:

not specified

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 400 L
- System of generating particulates/aerosols: heating of 20 g of the test item up to 150°C

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

4 h

Concentrations:

2.25 mg/L

No. of animals per sex per dose:

1 cat, 1 rabbit, 1 guinea pig, 2 rats and 4 mice

Control animals:

no

Details on study design:

- Other examinations performed: clinical signs

Results and discussion

Effect levels

Effect levels 1

Sex:

not specified

Dose descriptor:

LC50

Effect level:

> 2.25 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: only dose tested, no animal regardless the species died during the study or showed signs of toxicity

Effect levels 2

Sex:

not specified

Dose descriptor:

LC0

Effect level:

>= 2.25 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: only dose tested, no animal regardless the species died during the study or showed signs of toxicity

Mortality:

none noted

Clinical signs:

other: no animal regardless the species showed any signs of toxicity

Applicant's summary and conclusion

Interpretation of results:

relatively harmless

Remarks:

Criteria used for interpretation of results: expert judgment

Conclusions:

Based on the available data, no absolute classification of the test item is possible. However, it can be stated that it does not need to be classified as acute toxic by inhalation category 1.

Executive summary:

In an acute inhalation toxicity study, 1 cat, 1 rabbit, 1 guinea pig, 2 rats and 4 mice were exposed by inhalation route to 2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan for 4 hours to whole body at a concentration of 2.25 mg/L.

 

LC₅₀> 2.25 mg/L

LC₀≥ 2.25 mg/L

No animal regardless the species died during the study or showed signs of toxicity.

 

2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan is classified as being of low toxicity.