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Diss Factsheets
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EC number: 203-728-9 | CAS number: 110-01-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In the key study (Bottcher 2009), the toxicity of tetrahydrothiophene to Danio rerio was not precisely determined as only one dose was used. The NOEC is 24 mg/L for Danio rerio and therefore demonstrates that fish are less sensitive than Daphnia.
Key value for chemical safety assessment
Additional information
Bottcher (2009) is a GLP-compliant study following OECD guideline 203. However, only one dose concentration is used, which means that the results are not precise. The dose concentration was chosen as the threshold concentration of 24 mg/l, which was the lowest relevant, existing EC50 value for acute algae or daphnia. This shows that Daphnia are more sensitive to tetrahydrothiophene than fish. The results are considered reliable and suitable for use for this endpoint.
The supporting study (Kuttler 1998) is a semi-static, 96 hour, GLP-compliant study which follows OECD guideline 203. Test media were prepared as WAF, but included analytical measurement of the exposure concentrations. The large spacing between the test concentrations means that the LC50 cannot be precisely determined. The LC0 is reported as 15 mg/l and the LC100 as 6128 mg/l.
Neither of these studies allow us to determine an LC50, however, Bottcher (2009) does demonstrate that fish are less sensitive to tetrahydrothiophene than Daphnia. Due to this, conducting a new acute fish study is not considered necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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